ArticleFrontiers in immunology2015
Regulated Expression of miR-155 is Required for iNKT Cell Development.
Article in Frontiers in immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Role of miR-155 in inflammatory autoimmune diseases: a comprehensive review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022Pooled it
- miR-155 aberrant expression impairs tumor rejection because of its targeting of ICOSL and multiple pathways implicated in the antitumor response.Pharmacological reviews · 2026Review
- B Cell Activation Results in IKK-Dependent, but Not c-Rel- or RelA-Dependent, Decreases in Transcription of the B Cell Tolerance-Inducing Gene Ets1.ImmunoHorizons · 2022Article
- TGF‑β1 affects the renal cancer miRNome and regulates tumor cells proliferation.International journal of molecular medicine · 2022Article
- microRNA dynamic expression regulates invariant NKT cells.Cellular and molecular life sciences : CMLS · 2021Review
- MicroRNA-155 Regulates MAIT1 and MAIT17 Cell Differentiation.Frontiers in cell and developmental biology · 2021Article
- miR-21 sustains CD28 signalling and low-affinity T-cell responses at the expense of self-tolerance.Clinical & translational immunology · 2021Article
- Article
- Role of miRNAs in Normal and Myasthenia Gravis Thymus.Frontiers in immunology · 2020Review
- MicroRNA-155 ControlsFrontiers in cell and developmental biology · 2020Article
- miR-183-96-182 Cluster Is Involved in Invariant NKT Cell Development, Maturation, and Effector Function.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Development of Unconventional T Cells Controlled by MicroRNA.Frontiers in immunology · 2019Review
- Transcriptional and epigenetic regulation of innate-like T lymphocyte development.Current opinion in immunology · 2018Review
- Invariant natural killer T-cell development and function with loss of microRNA-155.Immunology · 2018Article
- MicroRNA Functions in Thymic Biology: Thymic Development and Involution.Frontiers in immunology · 2018Review
- miR-17∼92 family clusters control iNKT cell ontogenesis via modulation of TGF-β signaling.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging.Oncotarget · 2015Review
- An update on the roles of transcription factor Ets1 in autoimmune diseases.WIREs mechanisms of diseaseReview
- Functional Role of MicroRNAs in Thymocyte Development.International archives of allergy and immunologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Invariant natural killer T cells (iNKT cells) are CD1d-restricted, lipid antigen-reactive T lymphocytes with immunoregulatory functions. iNKT cell development in the thymus proceeds through subsequent stages, defined by the expression of CD44 and NK1.1, and is dictated by a unique gene expression program, including microRNAs. Here, we investigated whether miR-155, a microRNA involved in differentiation of most hematopoietic cells, played any role in iNKT cell development. To this end, we assessed the expression of miR-155 along iNKT cell maturation in the thymus, and studied the effects of miR-155 on iNKT cell development using Lck-miR-155 transgenic mice, which over express miR-155 in T cell lineage under the lymphocyte-specific protein tyrosine kinase (Lck) promoter. We show that miR-155 is expressed by newly selected immature wild-type iNKT cells and turned off along iNKT cells differentiation. In transgenic mice, miR-155 over-expression resulted in a substantial block of iNKT cell maturation at Stage 2, in the thymus toward an overall reduction of peripheral iNKT cells, unlike mainstream T cells. Furthermore, the effects of miR-155 over-expression on iNKT cell differentiation were cell autonomous. Finally, we identified Ets1 and ITK transcripts as relevant targets of miR-155 in iNKT cell differentiation. Altogether, these results demonstrate that a tight control of miR-155 expression is required for the development of iNKT cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.