ArticleFrontiers in aging neuroscience2015
Aging impairs deliberation and behavioral flexibility in inter-temporal choice.
Article in Frontiers in aging neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Deterministic dynamics of distributional multi-agent reinforcement learning.PLoS computational biology · 2026Article
- Large-scale coupling of prefrontal activity patterns as a mechanism for cognitive control in health and disease: evidence from rodent models.Frontiers in neural circuits · 2024Review
- Social isolation reinforces aging-related behavioral inflexibility by promoting neuronal necroptosis in basolateral amygdala.Molecular psychiatry · 2022Article
- Decreased investigatory head scanning during exploration in learning-impaired, aged rats.Neurobiology of aging · 2021Article
- Dorsomedial prefrontal cortex and hippocampus represent strategic context even while simultaneously changing representation throughout a task session.Neurobiology of learning and memory · 2020Article
- The perirhinal cortex supports spatial intertemporal choice stability.Neurobiology of learning and memory · 2019Article
- Trait determinants of impulsive behavior: a comprehensive analysis of 188 rats.Scientific reports · 2018Article
- Decline of prefrontal cortical-mediated executive functions but attenuated delay discounting in aged Fischer 344 × brown Norway hybrid rats.Neurobiology of aging · 2017Article
- Indomethacin Increases Neurogenesis across Age Groups and Improves Delayed Probe Trial Difference Scores in Middle-Aged Rats.Frontiers in aging neuroscience · 2017Article
- Interplay between Hippocampal Sharp-Wave-Ripple Events and Vicarious Trial and Error Behaviors in Decision Making.Neuron · 2016Article
- Lasting Adaptations in Social Behavior Produced by Social Disruption and Inhibition of Adult Neurogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Vicarious trial and error.Nature reviews. Neuroscience · 2016Review
- Reconsidering Animal Models of Major Depressive Disorder in the Elderly.Frontiers in aging neuroscience · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Inter-temporal choice depends on multiple, interacting systems, some of which may be compromised with age. Some of these systems may be responsible for ongoing trial-by-trial choice strategies. Some may represent the consequences of action. Some may be necessary for the coupling between anticipated consequences and strategies currently in use, flexibly guiding behavior. When faced with a difficult decision, rats will orient back and forth, a behavior termed "vicarious trial and error" (VTE). Recent experiments have linked the occurrence of VTE to hippocampal search processes and behavioral flexibility. We tested 5 month (n = 6), 9 month (n = 8) and over-27 month-old (n = 10) rats on a Spatial Adjusting Delay Discounting task to examine how aging impacted lap-by-lap strategies and VTE during inter-temporal choice. Rats chose between spatially separated food goals that provided a smaller-sooner or larger-later reward. On each lap, the delay to the larger-later reward was adjusted as a function of the rat's decisions, increasing by 1 s after delayed-side choices and decreasing by 1 s after non-delayed side choices. The strategies that aged rats used differed from those used in young and adult rats. Moreover, aged rats produced reliably more VTE behaviors, for protracted periods of time, uncoupled from behavioral flexibility.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.