ArticleMateria socio-medica2015
Frequency of class 1 integron in Escherichia coli strains isolated from patients with urinary tract infections in north of iran.
Article in Materia socio-medica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 22 citations in OpenAlex.
- Genomic insights into multidrug resistance in clinicalFrontiers in microbiology · 2026Article
- Integron and its role in antimicrobial resistance: A literature review on some bacterial pathogens.Iranian journal of basic medical sciences · 2021Review
- Class I integrons among multidrug resistantCaspian journal of internal medicine · 2021Article
- Pattern of Antibacterial Resistance in Urinary Tract Infections: A Systematic Review and Meta-analysis.International journal of preventive medicine · 2019Review
- Resistance integrons; A Mini review.Caspian journal of internal medicine · 2019Review
- Detection of Antimicrobial Susceptibility and Integrons Among Extended-spectrum β-lactamase Producing UropathogenicOman medical journal · 2018Article
- Integron-Mediated Antibiotic Resistance inBioMed research international · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDue to the importance of antibiotic resistance in E.coli and the possible role of integrons in creating of resistance, this study was performed to survey of class 1 integron in E. coli strains and their resistance to three routinely used antibiotics.
methodsIn this cross-sectional study, 100 strains of E. coli were isolated from patients with Urinary tract infection. After diagnosis of bacteria, genomes were extracted. Then, presence of integron class 1 was evaluated by using PCR. Antibiotic susceptibility testing method, the micro dilution broth was performed according to the standard CLSI2010. Data were analyzed using SPSS16 software.
resultOut of the total number of 100 E. coli cases, 22 cases (22%) had class 1 integron. Resistance against cotrimoxazol, cefixime and ciprofloxacin antibiotics were 67%, 34% and 34% respectively. In 22 E. coli cases positive for integron class1 gene, resistance against three antibiotics were 100%, 95.45% and 90.90% respectively, which is statistically significant (p < 0.05).
conclusionResistance level against antibiotics in samples containing class 1 integron were significantly higher than those lacking this gene, which may be confirm the present of class 1 integron in creation of clinical strains with resistance to this antibiotics. Using suitable antibiotics may be preventing transmission of resistance genes through integrons.
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