ArticleProceedings of the National Academy of Sciences of the United States of America2015
Host attachment and fluid shear are integrated into a mechanical signal regulating virulence in Escherichia coli O157:H7.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 117 citations in OpenAlex.
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- Flow-induced bending of flagella restrictsmBio · 2026Article
- An anaerobic in vitro flow model for studying interactions at the gastrointestinal host-microbe interface.NPJ biofilms and microbiomes · 2025Article
- Shear flow patterns antimicrobial gradients across bacterial populations.Science advances · 2025Article
- Combining multiple stressors blocks bacterial migration and growth.Current biology : CB · 2024Article
- Effects of fluid shear stress on oral biofilm formation and composition and the transcriptional response of Streptococcus gordonii.Molecular oral microbiology · 2024Article
- Microbiology of human spaceflight: microbial responses to mechanical forces that impact health and habitat sustainability.Microbiology and molecular biology reviews : MMBR · 2024Review
- ThemSphere · 2024Article
- Microgravity and evasion of plant innate immunity by human bacterial pathogens.NPJ microgravity · 2023Review
- Mechanobiology as a tool for addressing the genotype-to-phenotype problem in microbiology.Biophysics reviews · 2023Review
- Article
- Bacteria in Fluid Flow.Journal of bacteriology · 2023Review
- Screening of Anti-Adhesion Agents for PathogenicJournal of microbiology and biotechnology · 2023Article
- Shear rate sensitizes bacterial pathogens to HProceedings of the National Academy of Sciences of the United States of America · 2023Article
- GrlR, a negative regulator in enteropathogenicFrontiers in microbiology · 2023Article
- Bacterial biofilms in the human body: prevalence and impacts on health and disease.Frontiers in cellular and infection microbiology · 2023Review
- The Power of Touch: Type 4 Pili, the von Willebrand A Domain, and Surface Sensing by Pseudomonas aeruginosa.Journal of bacteriology · 2022Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Enterohemorrhagic Escherichia coli (EHEC) is a foodborne pathogen causing hemorrhagic colitis and hemolytic uremic syndrome. EHEC colonizes the intestinal tract through a range of virulence factors encoded by the locus of enterocyte effacement (LEE), as well as Shiga toxin. Although the factors involved in colonization and disease are well characterized, how EHEC regulates its expression in response to a host encounter is not well understood. Here, we report that EHEC perceives attachment to host cells as a mechanical cue that leads to expression of LEE-encoded virulence genes. This signal is transduced via the LEE-encoded global regulator of LEE-encoded regulator (Ler) and global regulator of Ler and is further enhanced by levels of shear force similar to peristaltic forces in the intestinal tract. Our data suggest that, in addition to a range of chemical environmental signals, EHEC is capable of sensing and responding to mechanical cues to adapt to its host's physiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.