ArticleProceedings of the National Academy of Sciences of the United States of America2015
Meteorite-catalyzed syntheses of nucleosides and of other prebiotic compounds from formamide under proton irradiation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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56 citing papers in PubMed, 187 citations in OpenAlex.
- From searching for extraterrestrial biosignatures to exploring the origins of life: A prebiotic chemistry perspective.Fundamental research · 2026Review
- Photochemistry of interstellar ice forming complex organic molecules.Nature reviews. Chemistry · 2025Review
- Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes.Chembiochem : a European journal of chemical biology · 2025Review
- Origin of the RNA World in Cold Hadean Geothermal Fields Enriched in Zinc and Potassium: Abiogenesis as a Positive Fallout from the Moon-Forming Impact?Life (Basel, Switzerland) · 2025Article
- Prospects of formamide as nitrogen source in biotechnological production processes.Applied microbiology and biotechnology · 2024Review
- Multicomponent Synthesis of C(8)-Substituted Purine Building Blocks of Peptide Nucleic Acids from Prebiotic Compounds.ChemistryOpen · 2024Article
- COAccounts of chemical research · 2024Article
- Light-Assisted Formation of Nucleosides and Nucleotides from Formamide in the Presence of Cerium Phosphate.Life (Basel, Switzerland) · 2024Article
- Infrared Spectral Signatures of Nucleobases in Interstellar Ices I: Purines.Life (Basel, Switzerland) · 2023Article
- Prebiotic Syntheses of Organophosphorus Compounds from Reduced Source of Phosphorus in Non-Aqueous Solvents.Life (Basel, Switzerland) · 2023Article
- Direct Synthesis of Formamide from COJournal of the American Chemical Society · 2023Article
- Prebiotic Synthesis ofJournal of the American Chemical Society · 2023Article
- Uracil in the carbonaceous asteroid (162173) Ryugu.Nature communications · 2023Article
- "Sea Water" Supplemented with Calcium Phosphate and Magnesium Sulfate in a Long-Term Miller-Type Experiment Yields Sugars, Nucleic Acids Bases, Nucleosides, Lipids, Amino Acids, and Oligopeptides.Life (Basel, Switzerland) · 2023Article
- Natural Radioactivity and Chemical Evolution on the Early Earth: Prebiotic Chemistry and Oxygenation.Molecules (Basel, Switzerland) · 2022Review
- How Did Life Emerge in Chemically Complex Messy Environments?Life (Basel, Switzerland) · 2022Article
- A Computational Quantum-Based Perspective on the Molecular Origins of Life's Building Blocks.Entropy (Basel, Switzerland) · 2022Review
- Identifying the wide diversity of extraterrestrial purine and pyrimidine nucleobases in carbonaceous meteorites.Nature communications · 2022Article
- Accurate Quantum Chemical Spectroscopic Characterization of Glycolic Acid: A Route Toward its Astrophysical Detection.The journal of physical chemistry. A · 2022Article
- Possible Ribose Synthesis in Carbonaceous Planetesimals.Life (Basel, Switzerland) · 2022Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Liquid formamide has been irradiated by high-energy proton beams in the presence of powdered meteorites, and the products of the catalyzed resulting syntheses were analyzed by mass spectrometry. Relative to the controls (no radiation, or no formamide, or no catalyst), an extremely rich, variegate, and prebiotically relevant panel of compounds was observed. The meteorites tested were representative of the four major classes: iron, stony iron, chondrites, and achondrites. The products obtained were amino acids, carboxylic acids, nucleobases, sugars, and, most notably, four nucleosides: cytidine, uridine, adenosine, and thymidine. In accordance with theoretical studies, the detection of HCN oligomers suggests the occurrence of mechanisms based on the generation of radical cyanide species (CN·) for the synthesis of nucleobases. Given that many of the compounds obtained are key components of extant organisms, these observations contribute to outline plausible exogenous high-energy-based prebiotic scenarios and their possible boundary conditions, as discussed.
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