ArticleHypertension (Dallas, Tex. : 1979)2015
Effect of bilateral carotid body resection on cardiac baroreflex control of blood pressure during hypoglycemia.
Article in Hypertension (Dallas, Tex. : 1979), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Sleep, Neural Circulatory Control, and Cardiovascular Disease: A Mechanistic Review.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- [Baroreflex failure syndrome after the resection of complex paragangliomas of head and neck: a case report].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024Article
- K252a Prevents Microglial Activation Induced by Anoxic Stimulation of Carotid Bodies in Rats.Toxics · 2023Article
- Perioperative blood pressure and heart rate alterations after carotid body tumor excision: a retrospective study of 108 cases.BMC anesthesiology · 2022Observational
- Arterial Baroreflex Inhibits Muscle Metaboreflex Induced Increases in Effective Arterial Elastance: Implications for Ventricular-Vascular Coupling.Frontiers in physiology · 2022Article
- Size of the Carotid Body in Patients with Cardiovascular and Respiratory Diseases Measured by Computed Tomography Angiography: A Case-Control Study.Radiology research and practice · 2021Article
- Carotid Body and Metabolic Syndrome: Mechanisms and Potential Therapeutic Targets.International journal of molecular sciences · 2020Review
- Variable role of carotid bodies in cardiovascular responses to exercise, hypoxia and hypercapnia in spontaneously hypertensive rats.The Journal of physiology · 2018Article
- Role of the carotid body chemoreceptors in glucose homeostasis and thermoregulation in humans.The Journal of physiology · 2018Review
- Glucose, insulin, and the carotid body chemoreceptors in humans.Physiological genomics · 2018Review
- Effects of intravenous low-dose dopamine infusion on glucose regulation during prolonged aerobic exercise.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Intact blood pressure, but not sympathetic, responsiveness to sympathoexcitatory stimuli in a patient with unilateral carotid body resection.Physiological reports · 2017Article
- Emerging concepts for patients with treatment-resistant hypertension.Trends in cardiovascular medicine · 2016Review
- Adrenaline release evokes hyperpnoea and an increase in ventilatory CO2 sensitivity during hypoglycaemia: a role for the carotid body.The Journal of physiology · 2016Article
- Interindividual variability in the dose-specific effect of dopamine on carotid chemoreceptor sensitivity to hypoxia.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Blood Pressure: Return of the Sympathetics?Current hypertension reports · 2016Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Hypoglycemia results in a reduction in cardiac baroreflex sensitivity and a shift in the baroreflex working range to higher heart rates. This effect is mediated, in part, by the carotid chemoreceptors. Therefore, we hypothesized hypoglycemia-mediated changes in baroreflex control of heart rate would be blunted in carotid body-resected patients when compared with healthy controls. Five patients with bilateral carotid body resection for glomus tumors and 10 healthy controls completed a 180-minute hyperinsulinemic, hypoglycemic (≈3.3 mmol/L) clamp. Changes in heart rate, blood pressure, and spontaneous cardiac baroreflex sensitivity were assessed. Baseline baroreflex sensitivity was not different between groups (P>0.05). Hypoglycemia resulted in a reduction in baroreflex sensitivity in both the groups (main effect of time, P<0.01) and responses were lower in resected patients when compared with controls (main effect of group, P<0.05). Hypoglycemia resulted in large reductions in systolic (-17±7 mm Hg) and mean (-14±5 mm Hg) blood pressure in resected patients that were not observed in controls (interaction of group and time, P<0.05). Despite lower blood pressures, increases in heart rate with hypoglycemia were blunted in resected patients (interaction of group and time, P<0.01). Major novel findings from this study demonstrate that intact carotid chemoreceptors are essential for increasing heart rate and maintaining arterial blood pressure during hypoglycemia in humans. These data support a contribution of the carotid chemoreceptors to blood pressure control and highlight the potential widespread effects of carotid body resection in humans.
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