Evidence map›Paper›PMID 25870067›Full record

ArticleAntimicrobial agents and chemotherapy2015

Antimalarial activity of tulathromycin in a murine model of malaria.

Nicolas Villarino, Joshua E Denny, Nathan W Schmidt

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Tulathromycin and Diclazuril Lack Efficacy againstPathogens (Basel, Switzerland) · 2023
    Article
  2. Article
  3. Article
  4. Article
  5. Assessment of DraxxinInternational journal for parasitology. Drugs and drug resistance · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Nicolas VillarinoDepartment of Microbiology, University of Tennessee, Knoxville, Tennessee, USA Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA.
Joshua E DennyDepartment of Microbiology, University of Tennessee, Knoxville, Tennessee, USA Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky, USA.
Nathan W SchmidtDepartment of Microbiology, University of Tennessee, Knoxville, Tennessee, USA Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky, USA nathan.schmidt@louisville.edu.
University of Tennessee at Knoxville · USWashington State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is an urgent need for new antimalarial agents and strategies to treat and control malaria. This study shows an antiplasmodium effect of tulathromycin in mice infected with Plasmodium yoelii. The administration of tulathromycin around the time of infection prevented the progression of disease in 100% of the animals. In addition, highly parasitized mice treated with tulathromycin showed a decreased parasite burden and cleared the parasite faster than did untreated infected mice.

Indexed as

AnimalsAntimalarialsDisaccharidesFemaleHeterocyclic CompoundsMacrolidesMalariaMicePlasmodium yoeliiAntimalarialsDisaccharidesHeterocyclic CompoundsMacrolidestulathromycin

Identifiers

PMID25870067
PMCPMC4432142
OpenAlexW2009913593

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.