ArticleAntimicrobial agents and chemotherapy2015
War wound treatment complications due to transfer of an IncN plasmid harboring bla(OXA-181) from Morganella morganii to CTX-M-27-producing sequence type 131 Escherichia coli.
Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Comprehensive genomic analysis of carbapenem-resistant Citrobacter freundii and characterization of a co-carrying blaBMC microbiology · 2026Article
- TnMicrobial genomics · 2024Article
- Longitudinal genomic surveillance of multidrug-resistantMicrobiology spectrum · 2024Article
- Diversity in the swimming motility and flagellar regulon structure of uropathogenic Morganella morganii strains.International microbiology : the official journal of the Spanish Society for Microbiology · 2022Article
- Emergence of oxacillinase-181 carbapenemase-producing diarrheagenicEmerging microbes & infections · 2021Article
- Emergence of carbapenem-resistantJournal of medical microbiology · 2021Article
- Emerging carbapenem-resistantMicrobial genomics · 2021Article
- Clinical Molecular and Genomic Epidemiology ofFrontiers in microbiology · 2021Article
- First Report of Coexistence ofFrontiers in microbiology · 2021Article
- Resistance ofFrontiers in microbiology · 2020Article
- The Global Ascendency of OXA-48-Type Carbapenemases.Clinical microbiology reviews · 2019Review
- Klebsiella pneumoniae ST307 with blaEmerging infectious diseases · 2019Article
- Screening and Characterization of Multidrug-Resistant Gram-Negative Bacteria from a Remote African Area, São Tomé and Príncipe.Antimicrobial agents and chemotherapy · 2018Article
- Multidrug-resistant Citrobacter freundii ST139 co-producing NDM-1 and CMY-152 from China.Scientific reports · 2018Article
- Antibacterial Activity of Human Simulated Epithelial Lining Fluid Concentrations of Ceftazidime-Avibactam Alone or in Combination with Amikacin Inhale (BAY41-6551) against Carbapenem-Resistant Pseudomonas aeruginosa and Klebsiella pneumoniae.Antimicrobial agents and chemotherapy · 2018Article
- Phenotypic and Genotypic Characterization of Enterobacteriaceae Producing Oxacillinase-48-Like Carbapenemases, United States.Emerging infectious diseases · 2018Article
- OXA-48-like carbapenemases producing Enterobacteriaceae in different niches.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Review
- Resistant Gram-Negative Bacteria and Diagnostic Point-of-Care Options for the Field Setting during Military Operations.BioMed research international · 2018Review
- Structure, activity and thermostability investigations of OXA-163, OXA-181 and OXA-245 using biochemical analysis, crystal structures and differential scanning calorimetry analysis.Acta crystallographica. Section F, Structural biology communications · 2017Article
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Abstract
A 22-year-old male developed a recurrent sacral abscess associated with embedded shrapnel following a blast injury. Cultures grew extended-spectrum β-lactamase (ESBL)-producing, carbapenem-susceptible Escherichia coli. Ertapenem was administered, but the infection recurred after each course of antibiotics. Initial surgical interventions were unsuccessful, and subsequent cultures yielded E. coli and Morganella morganii, both nonsusceptible to carbapenems. The isolates were Carba NP test negative, gave ambiguous results with the modified Hodge test, and amplified the bla(OXA48)-like gene by real-time PCR. All E. coli isolates were sequence type 131 (ST131), carried nine resistance genes (including bla(CTX-M-27)) on an IncF plasmid, and were identical by genome sequencing, except for 150 kb of plasmid DNA in carbapenem-nonsusceptible isolates only. Sixty kilobases of this was shared by M. morganii and represented an IncN plasmid harboring bla(OXA-181). In M. morganii, the gene was flanked by IS3000 and ISKpn19, but in all but one of the E. coli isolates containing bla(OXA-181), a second copy of ISKpn19 had inserted adjacent to IS3000. To the best of our knowledge, this is the first report of bla(OXA-181) in the virulent ST131 clonal group and carried by the promiscuous IncN family of plasmids. The tendency of M. morganii to have high MICs of imipenem, a bla(OXA-181) substrate profile that includes penicillins but not extended-spectrum cephalosporins, and weak carbapenemase activity almost resulted in the presence of bla(OXA-181) being overlooked. We highlight the importance of surveillance for carbapenem resistance in all species, even those with intrinsic resistances, and the value of advanced molecular techniques in detecting subtle genetic changes.
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