Trial reportMolecular psychiatry2016
Valence-dependent influence of serotonin depletion on model-based choice strategy.
Trial report in Molecular psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Serotonergic Modulation of Cognition, Emotion and Brain Activation in Healthy Volunteers
The Role of Serotonin in Compulsive Behavior in Humans: Underlying Brain Mechanisms
Who cites it
44 citing papers in PubMed.
- Arbitration between model-free and model-based control is not affected by transient changes in tonic serotonin levels.Journal of psychopharmacology (Oxford, England) · 2024Trial
- Chronic escitalopram in healthy volunteers has specific effects on reinforcement sensitivity: a double-blind, placebo-controlled semi-randomised study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Serotonin depletion impairs both Pavlovian and instrumental reversal learning in healthy humans.Molecular psychiatry · 2021Trial
- Reward and avoidance learning in the context of aversive environments and possible implications for depressive symptoms.Psychopharmacology · 2019Trial
- Beyond negative valence: 2-week administration of a serotonergic antidepressant enhances both reward and effort learning signals.PLoS biology · 2017Trial
- Trial
- Altered cognitive response to serotonin challenge as a candidate endophenotype for obsessive-compulsive disorder.Psychopharmacology · 2016Trial
- Disentangling the Component Processes in Complex Planning Impairments Following Ventromedial Prefrontal Lesions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Complementary roles of serotonin and dopamine in model-based learning.Current opinion in behavioral sciences · 2025Article
- Emotional words evoke region- and valence-specific patterns of concurrent neuromodulator release in human thalamus and cortex.Cell reports · 2025Article
- Direct serotonin release in humans shapes aversive learning and inhibition.Nature communications · 2024Article
- Impact of Pharmacogenetic Testing on Clozapine Treatment Efficacy in Patients with Treatment-Resistant Schizophrenia.Biomedicines · 2024Article
- Comparable roles for serotonin in rats and humans for computations underlying flexible decision-making.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- The involvement of serotonin in major depression: nescience in disguise?Molecular psychiatry · 2024Article
- Dorsal raphe neurons signal integrated value during multi-attribute decision-making.bioRxiv : the preprint server for biology · 2023Article
- Opponent learning with different representations in the cortico-basal ganglia pathways can develop obsession-compulsion cycle.PLoS computational biology · 2023Article
- Cortical Grey Matter Mediates Increases in Model-Based Control and Learning from Positive Feedback from Adolescence to Adulthood.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Distinct reinforcement learning profiles distinguish between language and attentional neurodevelopmental disorders.Behavioral and brain functions : BBF · 2023Article
- Model-based prioritization for acquiring protection.PLoS computational biology · 2022Article
- Explicit knowledge of task structure is a primary determinant of human model-based action.Nature human behaviour · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Human decision-making arises from both reflective and reflexive mechanisms, which underpin goal-directed and habitual behavioural control. Computationally, these two systems of behavioural control have been described by different learning algorithms, model-based and model-free learning, respectively. Here, we investigated the effect of diminished serotonin (5-hydroxytryptamine) neurotransmission using dietary tryptophan depletion (TD) in healthy volunteers on the performance of a two-stage decision-making task, which allows discrimination between model-free and model-based behavioural strategies. A novel version of the task was used, which not only examined choice balance for monetary reward but also for punishment (monetary loss). TD impaired goal-directed (model-based) behaviour in the reward condition, but promoted it under punishment. This effect on appetitive and aversive goal-directed behaviour is likely mediated by alteration of the average reward representation produced by TD, which is consistent with previous studies. Overall, the major implication of this study is that serotonin differentially affects goal-directed learning as a function of affective valence. These findings are relevant for a further understanding of psychiatric disorders associated with breakdown of goal-directed behavioural control such as obsessive-compulsive disorders or addictions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.