Evidence map›Paper›PMID 25869804›Full record

ArticleMolecular psychiatry2016

GWAS for executive function and processing speed suggests involvement of the CADM2 gene.

C A Ibrahim-Verbaas, J Bressler, S Debette, M Schuur, A V Smith, J C Bis, G Davies, S Trompet, J A Smith, C Wolf and 117 more

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 13 pooled it
14.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 13 syntheses or guidelines pooled it, 158 citations in OpenAlex.

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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

127 authors at 20 institutions in 14 countries.

C A Ibrahim-VerbaasGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
J BresslerHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
S DebetteDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA.
M SchuurGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
A V SmithIcelandic Heart Association, Kopavogur, Iceland.
J C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
G DaviesCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.
S TrompetDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
J A SmithDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
C WolfRG Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany.
L B ChibnikProgram in Translational Neuropsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Y LiuDepartment of Epidemiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
V VitartMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
M KirinCentre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
K PetrovicDepartment of Neurology, Medical University and General Hospital of Graz, Graz, Austria.
O PolasekDepartment of Public Health, University of Split, Split, Croatia.
L ZgagaDepartment of Public Health and Primary Care, Trinity College Dublin, Dublin, Ireland.
C Fawns-RitchieCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.
P HoffmannInstitute of Neuroscience and Medicine (INM -1), Research Center Juelich, Juelich, Germany.
J KarjalainenDepartment of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
J LahtiInstitute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.
D J LlewellynInstitute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, UK.
C O SchmidtInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
K A MatherCentre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.
V ChourakiInserm, U1167, Institut Pasteur de Lille, Université Lille-Nord de France, Lille, France.
Q SunChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
S M ResnickLaboratory of Behavioral Neuroscience, National Institute on Aging, NIH, Baltimore, MD, USA.
L M RoseDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
C OldmeadowHunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.
M StewartCentre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
B H SmithMedical Research Institute, University of Dundee, Dundee, UK.
V GudnasonIcelandic Heart Association, Kopavogur, Iceland.
Q YangThe National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.
S S MirzaDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
J W JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
P L deJagerProgram in Translational Neuropsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
T B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA.
D C LiewaldCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.
N AminGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
L H CokerDivision of Public Health Sciences and Neurology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
O StegleMax Planck Institute for Developmental Biology, Max Planck Institute for Intelligent Systems, Tübingen, Germany.
O L LopezDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
R SchmidtDepartment of Neurology, Medical University and General Hospital of Graz, Graz, Austria.
A TeumerInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
I FordRobertson Center for biostatistics, University of Glasgow, Glasgow, UK.
N KarbalaiRG Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany.
J T BeckerDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
M K JonsdottirLandspitali Hospital, Reykjavik, Iceland.
R AuDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA.
Rsn FehrmannDepartment of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
S HermsDivision of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.
M NallsLaboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.
W ZhaoDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
S T TurnerDivision of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
K YaffeDepartments of Psychiatry, Neurology and Epidemiology, University of California, San Francisco and San Francisco VA Medical Center, San Francisco, CA, USA.
K LohmanDepartment of Epidemiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
J C van SwietenDepartment of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Slr KardiaDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
D S KnopmanDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
W M MeeksDepartment of Medicine, Division of Geriatrics, University of Mississippi Medical Center, Jackson, MS, USA.
G HeissDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
E G HollidayHunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.
P W SchofieldSchool of Medicine and Public Health, Faculty of Health, University of Newcastle, Newcastle, SW, Australia.
T TanakaTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
D J StottDepartment of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
J WangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
P RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
A J GowCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.
A PattieCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.
J M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.
L J HockingDivision of Applied Medicine, University of Aberdeen, Aberdeen, UK.
N J ArmstrongCentre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.
S McLachlanCentre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
J M ShulmanDepartment of Neurology, Baylor College of Medicine, Houston, TX, USA.
L C PillingEpidemiology and Public Health Group, University of Exeter Medical School, Exeter, UK.
G EiriksdottirIcelandic Heart Association, Kopavogur, Iceland.
R J ScottHunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.
N A KochanCentre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.
A PalotieWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
Y-C HsiehSchool of Public Health, Taipei Medical University, Taipei, Taiwan.
J G ErikssonFolkhälsan Research Centre, Helsinki, Finland.
A PenmanCenter of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, MS, USA.
R F GottesmanDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
B A OostraGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
L YuRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
A L DeStefanoDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA.
A BeiserDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA.
M GarciaLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA.
J I RotterMedical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
M M NöthenDepartment of Genomics, Life and Brain Research Center, Institute of Human Genetics, University of Bonn, Bonn, Germany.
A HofmanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
P E SlagboomDepartment of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Rgj WestendorpLeiden Academy of Vitality and Ageing, Leiden, The Netherlands.
B M BuckleyDepartment of Pharmacology and Therapeutics, University College Cork, Cork, Ireland.
P A WolfDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA.
A G UitterlindenDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
B M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
H J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS-Hospital Stralsund, Stralsund, Germany.
S BandinelliGeriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.
D I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
F GrodsteinChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
K RäikkönenInstitute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.
J-C LambertInserm, U1167, Institut Pasteur de Lille, Université Lille-Nord de France, Lille, France.
D J PorteousCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Generation Scotland
J F PriceCentre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
P S SachdevCentre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.
L FerrucciTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
J R AttiaHunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.
I RudanCentre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
C HaywardMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
A F WrightMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
J F WilsonCentre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
S CichonDivision of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.
L FrankeDepartment of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
H SchmidtDepartment of Neurology, Medical University and General Hospital of Graz, Graz, Austria.
J DingDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Ajm de CraenDepartment of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
M FornageInstitute for Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.
D A Bennett *Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
I J Deary *Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.
M A Ikram *Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.
L J Launer *Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA.
A L Fitzpatrick *Department of Epidemiology, University of Washington, Seattle, WA, USA.
S Seshadri *Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
C M van Duijn *Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
T H Mosley *Department of Medicine and Neurology, University of Mississippi Medical Center, Jackson, MS, USA.
Erasmus MC · NLBoston University · USUniversity of Edinburgh · GBBrigham and Women's Hospital · USHunter Medical Research Institute · AULeiden University Medical Center · NLNational Institute on Aging · USInstitute of Genetics and Cancer · GBUniversity Medical Center Groningen · NLUniversity of Bonn · DEUniversity of Helsinki · FIUNSW Sydney · AUAzienda Sanitaria di Firenze · ITMedical University of Graz · ATRush University Medical Center · USUniversity of Michigan · USUniversity of Mississippi Medical Center · USWake Forest University · USInserm · FRMax Planck Institute of Psychiatry · DE

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI LEURGANS, SUE E. · 1991 to 2020
$49.1M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
TREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAMBOH, M. ILYAS · 1985 to 2019
$43.0M
Validity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLETT, WALTER C. · 1991 to 2009
$41.8M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI ALBERT, MARILYN S. · 1985 to 2019
$37.6M
Risk Factors for Breast Cancer in Younger NursesR01CA050385 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 1989 to 2019
$32.3M
UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3M
Biotechnology and Biological Sciences Research Council BB/F019394/1British Heart FoundationChief Scientist Office CZB/4/505Chief Scientist Office CZD/16/6Chief Scientist Office CZD/16/6/4Chief Scientist Office ETM/55Intramural NIH HHSMedical Research Council G0700704Medical Research Council MC_PC_U127561128Medical Research Council MR/K026992/1NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCI NIH HHS 5UO1CA098233NCI NIH HHS CA047988NCI NIH HHS CA134958NCI NIH HHS CA49449NCI NIH HHS CA50385NCI NIH HHS CA55075NCI NIH HHS CA65725NCI NIH HHS CA67262NCI NIH HHS CA87969NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCI NIH HHS R01 CA047988NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA050385NCI NIH HHS R01 CA065725NCI NIH HHS R01 CA067262NCI NIH HHS R01 CA134958NCI NIH HHS R21 CA139035NCI NIH HHS U01 CA049449NCI NIH HHS U01 CA067262NCI NIH HHS U01 CA098233NCI NIH HHS UM1 CA182913NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1RR025005NEI NIH HHS EY015473NEI NIH HHS EY09611NEI NIH HHS R01 EY009611NEI NIH HHS R01 EY015473NHGRI NIH HHS HG004728NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004399NHGRI NIH HHS U01HG004399NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01HG004402NHGRI NIH HHS U01 HG004728NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HL054457NHLBI NIH HHS HL054464NHLBI NIH HHS HL054481NHLBI NIH HHS HL071917NHLBI NIH HHS HL080467NHLBI NIH HHS HL34594NHLBI NIH HHS HL35464NHLBI NIH HHS HL87660NHLBI NIH HHS K99 HL098459NHLBI NIH HHS K99HL098459NHLBI NIH HHS N01 HC015103NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC035129NHLBI NIH HHS N01 HC045133NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC075150NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085084NHLBI NIH HHS N01 HC085085NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01-HC-25195NHLBI NIH HHS N02-HL-6-4278NHLBI NIH HHS R01 HL034594NHLBI NIH HHS R01 HL035464NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL070825NHLBI NIH HHS R01 HL071917NHLBI NIH HHS R01 HL080295NHLBI NIH HHS R01 HL080467NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01HL087652NHLBI NIH HHS R01 HL087660NHLBI NIH HHS R01 HL093029NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01HL120393NHLBI NIH HHS R01HL59367NHLBI NIH HHS R01HL70825NHLBI NIH HHS U01 HL054457NHLBI NIH HHS U01 HL054463NHLBI NIH HHS U01 HL054464NHLBI NIH HHS U01 HL054481NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096814NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917NHLBI NIH HHS U10 HL054457NHLBI NIH HHS U10 HL054464NHLBI NIH HHS U10 HL054481NIA NIH HHS 1R01AG032098-01A1NIA NIH HHS AG008122NIA NIH HHS AG033193NIA NIH HHS AG16495NIA NIH HHS K08 AG034290NIA NIH HHS K08AG34290NIA NIH HHS K25 AG041906NIA NIH HHS K25AG41906NIA NIH HHS N01 AG012100NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS N01 AG821336NIA NIH HHS N01[AG] 821336NIA NIH HHS N01 AG916413NIA NIH HHS N01[AG]916413NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG010161NIA NIH HHS P30AG10161NIA NIH HHS P50 AG005133NIA NIH HHS P50 AG005146NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG015928NIA NIH HHS R01 AG016495NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG020098NIA NIH HHS R01 AG023629NIA NIH HHS R01AG023629NIA NIH HHS R01 AG027058NIA NIH HHS R01AG027058NIA NIH HHS R01 AG030146NIA NIH HHS R01 AG032098NIA NIH HHS R01 AG033193NIA NIH HHS R01 AG054076NIA NIH HHS R01AG15819NIA NIH HHS R01AG15928NIA NIH HHS R01AG17917NIA NIH HHS R01AG20098NIA NIH HHS R01AG30146NIA NIH HHS U01 AG049505NIDDK NIH HHS DK058845NIDDK NIH HHS DK063491NIDDK NIH HHS DK070756NIDDK NIH HHS P01 DK070756NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK058845NIMHD NIH HHS 263 MD 821336NIMHD NIH HHS R01 MD009164NINDS NIH HHS NS041558NINDS NIH HHS NS17950NINDS NIH HHS R01 NS017950NINDS NIH HHS R01 NS041558PHS HHS HHSN268200625226CPHS HHS NHLBIU01HL080295Wellcome TrustWellcome Trust WT089062
6 · The paper itself

Abstract

To identify common variants contributing to normal variation in two specific domains of cognitive functioning, we conducted a genome-wide association study (GWAS) of executive functioning and information processing speed in non-demented older adults from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) consortium. Neuropsychological testing was available for 5429-32,070 subjects of European ancestry aged 45 years or older, free of dementia and clinical stroke at the time of cognitive testing from 20 cohorts in the discovery phase. We analyzed performance on the Trail Making Test parts A and B, the Letter Digit Substitution Test (LDST), the Digit Symbol Substitution Task (DSST), semantic and phonemic fluency tests, and the Stroop Color and Word Test. Replication was sought in 1311-21860 subjects from 20 independent cohorts. A significant association was observed in the discovery cohorts for the single-nucleotide polymorphism (SNP) rs17518584 (discovery P-value=3.12 × 10(-8)) and in the joint discovery and replication meta-analysis (P-value=3.28 × 10(-9) after adjustment for age, gender and education) in an intron of the gene cell adhesion molecule 2 (CADM2) for performance on the LDST/DSST. Rs17518584 is located about 170 kb upstream of the transcription start site of the major transcript for the CADM2 gene, but is within an intron of a variant transcript that includes an alternative first exon. The variant is associated with expression of CADM2 in the cingulate cortex (P-value=4 × 10(-4)). The protein encoded by CADM2 is involved in glutamate signaling (P-value=7.22 × 10(-15)), gamma-aminobutyric acid (GABA) transport (P-value=1.36 × 10(-11)) and neuron cell-cell adhesion (P-value=1.48 × 10(-13)). Our findings suggest that genetic variation in the CADM2 gene is associated with individual differences in information processing speed.

Indexed as

AgedAged, 80 and overCell Adhesion MoleculesCognitionCohort StudiesExecutive FunctionFemalegamma-Aminobutyric AcidGenetic Association StudiesGenetic VariationGenome-Wide Association StudyGenomicsHumansIntronsMaleMiddle AgedCADM2 protein, humanCell Adhesion Moleculesgamma-Aminobutyric Acid

Identifiers

PMID25869804
PMCPMC4722802
OpenAlexW2001740985

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