Evidence map›Paper›PMID 25869759›Full record

Trial reportWiener klinische Wochenschrift2016

Nonalcoholic fatty liver may increase the risk of operation in patients with fatty liver and the frequency of cancer in their first-degree relatives.

Metin Basaranoglu, Billur Canbakan, Kemal Yildiz, Bahadir Ceylan, Birol Baysal, Omer Uysal, Hakan Senturk

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Wiener klinische Wochenschrift, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Observational
  2. Article
  3. A Comparative Study of Laparoscopic and Open Approaches for Right Hemihepatectomy in Hepatocellular Carcinoma Patients: Safety and Short-Term Outcomes.Medical science monitor : international medical journal of experimental and clinical research · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Metin BasaranogluDivision of Gastroenterology, Department of Internal Medicine, Medical School, BezmiAlem Vakif University, 34000, Istanbul, Turkey. metin_basaranoglu@yahoo.com.
Billur CanbakanDivision of Gastroenterology, Department of Internal Medicine, Medical School, BezmiAlem Vakif University, 34000, Istanbul, Turkey.
Kemal YildizDivision of Gastroenterology, Department of Internal Medicine, Medical School, BezmiAlem Vakif University, 34000, Istanbul, Turkey.
Bahadir CeylanDivision of Gastroenterology, Department of Internal Medicine, Medical School, BezmiAlem Vakif University, 34000, Istanbul, Turkey.
Birol BaysalDivision of Gastroenterology, Department of Internal Medicine, Medical School, BezmiAlem Vakif University, 34000, Istanbul, Turkey.
Omer UysalDivision of Gastroenterology, Department of Internal Medicine, Medical School, BezmiAlem Vakif University, 34000, Istanbul, Turkey.
Hakan SenturkDivision of Gastroenterology, Department of Internal Medicine, Medical School, BezmiAlem Vakif University, 34000, Istanbul, Turkey.
Bezmiâlem Vakıf Üniversitesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFatty liver is a common disease in developed countries. We investigated the frequency of operation in patients with fatty liver and the frequency of cancer in their first-degree relatives.

methodsIn this study, we evaluated 105 patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD), 121 patients with hepatitis C (61 patients with fatty liver and 60 patients without fatty liver), 50 patients with inflammatory bowel disease (IBD), and 109 patients with dyspepsia as a control group.

resultsThere was no difference for sex, mean age, and marital status among the groups, except that patients with IBD were younger than others (p < 0.001). The frequency of cancer in family was as follows: 18 % in IBD, 9 % in dyspepsia, 28 % in hepatitis C with hepatic steatosis, 21.5 % in hepatitis C without steatosis, and 27 % in NAFLD (p = 0.006). Then, we divided the study group into two groups-group 1: IBD + dyspepsia + hepatitis C without hepatic steatosis, and group 2: hepatitis C with hepatic steatosis + NAFLD-and performed the same analysis. We found that the frequency of cancer in family was 16 % in group 1 (the patients without fatty liver) vs. 24.4 % in group 2 (those with fatty liver; p = 0.037). We also investigated the rate of operation in patients. The results were as follows: 33 % in group 1 vs. 43 % in group 2 (p = 0.043).

conclusionsIndependently of the underlying chronic diseases, occurrence of fat in the liver increased the frequency of operation in patients with fatty liver and the rate of cancer in their first-degree relatives. Understanding the underlying causes of fatty liver forms might decrease the cancer frequency in the population and number of operation in patients with fatty liver.

Indexed as

AdultAgedComorbidityFemaleGenetic Predisposition to DiseaseHepatectomyHumansIncidenceLiver NeoplasmsMaleMiddle AgedNon-alcoholic Fatty Liver DiseasePrevalenceRisk FactorsTurkeyUtilization ReviewCancerDyspepsiaFatty liverHepatitis CInflammatory bowel diseaseNonalcoholic fatty liver diseaseOperationSurgery

Identifiers

PMID25869759
OpenAlexW2093272464

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.