Evidence map›Paper›PMID 25869605›Full record

ArticleInternational journal of obesity (2005)2015

High sodium intake is associated with short leukocyte telomere length in overweight and obese adolescents.

H Zhu, J Bhagatwala, N K Pollock, S Parikh, B Gutin, I Stallmann-Jorgensen, J Thomas, G A Harshfield, Y Dong

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PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of obesity (2005), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 4 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

H ZhuGeorgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA.
J Bhagatwala1] Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA [2] Internal Medicine, Department of Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA.
N K PollockGeorgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA.
S Parikh1] Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA [2] Internal Medicine, Department of Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA.
B GutinGeorgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA.
I Stallmann-JorgensenDepartment of Physiology, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA.
J ThomasGeorgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA.
G A HarshfieldGeorgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA.
Y DongGeorgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA.
Augusta University · US

Funding

LIFESTYLE, ADIPOSITY AND CARDIOVASCULAR HEALTH IN YOUTHSR01HL064157 · NHLBI · MEDICAL COLLEGE OF GEORGIA (MCG) · PI GUTIN, BERNARD · 2000 to 2003
$2.6M
NHLBI NIH HHS HL064157NHLBI NIH HHS R01 HL064157
6 · The paper itself

Abstract

BACKGROUND/

objectivesTelomere shortening has an important role in cellular aging. However, the impact of high sodium intake, an important risk factor of age-related diseases, on telomere shortening remains unknown. Therefore, we examined the relationship between high dietary sodium intake and leukocyte telomere length (LTL), particularly in the context of obesity, as obesity increases salt sensitivity. SUBJECTS/

methodsLTL was determined by a quantitative polymerase chain reaction method in 766 adolescents aged 14-18 years (50% females, 49% African Americans). Dietary sodium intake was assessed by seven independent 24-h dietary recalls. We divided the sample into low sodium (mean 2388±522 mg per day) or high sodium groups (mean 4142±882 mg per day) based on the median value (3280.9 mg per day).

resultsIn the entire cohort, there was no significant association between sodium intake and LTL (r=-0.05, P=0.24). However, there was a significant interaction between sodium intake and obesity status (P=0.049). Further multiple linear regression analyses revealed that higher dietary sodium intake was associated with shorter LTL in the overweight/obese group (body mass index ⩾85th percentile, β=-0.37, P=0.04), but not in the normal-weight group (β=0.01, P=0.93) after adjusting for multiple confounding factors. In the overweight/obese group, LTL was significantly shorter in the high sodium intake subjects vs low sodium intake subjects (1.24±0.22 vs. 1.32±0.20, P=0.02), but not the normal-weight group (1.29±0.24 vs 1.30±0.24, P=0.69).

conclusionsHigher dietary sodium intake is associated with shorter telomere length in overweight and obese adolescents.

Indexed as

Telomere ShorteningAdolescentBody Mass IndexCellular SenescenceDietFemaleGeorgiaHumansLeukocytesMalePediatric ObesitySodium, DietaryTelomereSodium, Dietary

Identifiers

PMID25869605
PMCPMC6344938
OpenAlexW2030487401

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.