ArticleDrug and alcohol dependence2015
Factors affecting repeated cessations of injecting drug use and relapses during the entire injecting career among the Edinburgh Addiction Cohort.
Article in Drug and alcohol dependence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Cannabis use and illicit opioid cessation among people who use drugs living with chronic pain.Drug and alcohol review · 2025Article
- Correlates of Six-Month Recidivism among Rural Incarcerated Women.Women & criminal justice · 2025Article
- Modeling the impact of the COVID-19 pandemic on achieving HCV elimination amongst young and unstably housed people who inject drugs in San Francisco.The International journal on drug policy · 2024Article
- Testing and Treatment Interventions in Community Settings Key to Controlling a Recent Human Immunodeficiency Virus Outbreak Among People Who Inject Drugs in Glasgow: A Modeling Study.The Journal of infectious diseases · 2024Article
- Injection cessation and relapse to injection and the associated factors among people who inject drugs in Iran: The Rostam study.Substance abuse treatment, prevention, and policy · 2023Article
- High rates of resumption of injecting drug use following release from prison among men who injected drugs before imprisonment.Addiction (Abingdon, England) · 2022Article
- Modelling the intervention effect of opioid agonist treatment on multiple mortality outcomes in people who inject drugs: a three-setting analysis.The lancet. Psychiatry · 2021Article
- Assessing Drug Consumption Rooms and Longer Term (5 Year) Impacts on Community and Clients.Risk management and healthcare policy · 2021Review
- Estimating the prevalence of problem drug use from drug-related mortality data.Addiction (Abingdon, England) · 2020Article
- Types of Medication-Assisted Treatment for Opioid Use Disorder in Turkey: The Perceptions of Inpatients about Treatment Success.Psychiatry investigation · 2020Article
- Trajectories of injection drug use among people who use drugs in Vancouver, Canada, 1996-2017: growth mixture modeling using data from prospective cohort studies.Addiction (Abingdon, England) · 2019Article
- Opioid agonist treatment scale-up and the initiation of injection drug use: A dynamic modeling analysis.PLoS medicine · 2019Article
- Supervised Injection Facility Utilization Patterns: A Prospective Cohort Study in Vancouver, Canada.American journal of preventive medicine · 2019Article
- Non drug-related and opioid-specific causes of 3262 deaths in Scotland's methadone-prescription clients, 2009-2015.Drug and alcohol dependence · 2019Article
- Modelling the impact of a national scale-up of interventions on hepatitis C virus transmission among people who inject drugs in Scotland.Addiction (Abingdon, England) · 2018Article
- A comparison of two biological markers of recent hepatitis C virus (HCV) infection: implications for the monitoring of interventions and strategies to reduce HCV transmission among people who inject drugs.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2018Article
- Predictors of transitions across stages of heroin use and dependence prior to treatment-seeking among people in treatment for opioid dependence.Drug and alcohol dependence · 2018Article
- The impact of buprenorphine and methadone on mortality: a primary care cohort study in the United Kingdom.Addiction (Abingdon, England) · 2018Article
- Predictors of injecting cessation among a cohort of people who inject drugs in Tijuana, Mexico.Drug and alcohol dependence · 2018Article
- 6th Canadian Symposium on Hepatitis C Virus: Delivering a cure for hepatitis C infection-What are the remaining gaps?Canadian liver journal · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimsInjecting drug use is a chronic condition, with people who inject drugs (PWID) typically experiencing repeated cessations and relapses during their injection careers. We characterize patterns of ceasing and relapsing and the impact of opiate substitution treatment (OST) during the entire injecting careers of PWID in the Edinburgh Addiction Cohort (EAC).
methodsDuring 2005-2007, 432 surviving participants of the EAC were interviewed about their injecting histories. Adjusted associations between covariates and hazards of cessation and relapse were estimated using random-effects models.
resultsOST was strongly associated with a higher hazard of cessation (HR = 1 .71, P < 0.001), but there was no significant evidence of association with hazard of relapse (HR = 0.81, P = 0.14). Women and older PWID were less likely to relapse (HR = 0.73, P = 0.02 and HR = 0.55, P < 0.001, respectively). Hazards of both cessation and relapse decreased monotonically with time since last relapse/cessation (both P < 0.001). An individual's hazard of cessation increased with his/her number of previous cessations (HR = 3.58 for 10+ previous cessations, P < 0.001), but there was no evidence that an individual's hazard of relapse changed with number of previous relapses (P = 0.37). There was heterogeneity in the individual hazards of both cessation and relapse.
conclusionsOST was associated with reduced time to cessation, and there was some suggestion of increased time to relapse too. The likelihood of prolonged cessation is greater for women, increases with age, and decreases with time since last relapse.
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