ArticlePediatrics2015
Outcomes and costs of surgical treatments of necrotizing enterocolitis.
Article in Pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed, 104 citations in OpenAlex.
- A Pathophysiological Approach for Early Detection and Prevention of AKI in the NICU.American journal of perinatology · 2026Review
- Live biotherapeutic product IBP-9414 (L. reuteri) in very low birth weight infants: the Connection Study.Pediatric research · 2026Article
- Application of Umbilical Cord Blood for the Clinical Prevention and Treatment of Complications in Preterm Infants(Review).Stem cell reviews and reports · 2026Review
- L-cystine alleviates necrotizing enterocolitis by regulating ferroptosis and Th17 cell differentiation via the IL-6/STAT3 pathway.Communications biology · 2025Article
- Digging deeper into necrotizing enterocolitis: bridging clinical, microbial, and molecular perspectives.Gut microbes · 2025Review
- Unplanned natural experiment: probiotics prevent necrotizing enterocolitis, a single center quality improvement report.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Detection of an intestinal cell DNA methylation signature in blood samples from neonates with necrotizing enterocolitis.Epigenomics · 2025Article
- Cost of operating a human milk bank in the UK: a microcosting analysis.Archives of disease in childhood. Fetal and neonatal edition · 2025Article
- The "pro" and "con" of probiotics, regulation and preterm infant health.Pediatric research · 2025Article
- Cannabidiol decreases histological intestinal injury in a neonatal experimental model of necrotizing enterocolitis.Laboratory animal research · 2024Article
- Impact of fetal inflammatory response on the severity of necrotizing enterocolitis in preterm infants.Pediatric research · 2024Article
- Natal factors affecting developmental defects of enamel in preterm infants: a prospective cohort study.Scientific reports · 2024Article
- Novel scoring system for early diagnosis of necrotizing enterocolitis: integrating clinical and laboratory data with urinary caveolin-1 levels.Archives of medical science : AMS · 2024Article
- Laparotomy versus Peritoneal Drainage as Primary Treatment for Surgical Necrotizing Enterocolitis or Spontaneous Intestinal Perforation in Preterm Neonates: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2023Review
- Opioid and Methadone Use for Infants With Surgically Treated Necrotizing Enterocolitis.JAMA network open · 2023Article
- Developing a resiliency model for survival without major morbidity in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Integrative analysis links ferroptosis to necrotizing enterocolitis and reveals the role ofiScience · 2022Article
- Selective hypermethylation is evident in small intestine samples from infants with necrotizing enterocolitis.Clinical epigenetics · 2022Article
- Growth of Very Preterm Infants in a Low-Resourced Rural Setting after Affiliation with a Human Milk Bank.Children (Basel, Switzerland) · 2022Article
- Advocating for donor milk access in Medicaid: bringing equity to the neonatal intensive care unit.Pediatric research · 2022Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesDespite previous studies demonstrating no difference in mortality or morbidity, the various surgical approaches for necrotizing enterocolitis (NEC) in infants have not been evaluated economically. Our goal was to compare total in-hospital cost and mortality by using propensity score-matched infants treated with peritoneal drainage alone, peritoneal drainage followed by laparotomy, or laparotomy alone for surgical NEC.
methodsUtilizing the California OSHPD Linked Birth File Dataset, 1375 infants with surgical NEC between 1999 and 2007 were retrospectively propensity score matched according to intervention type. Total in-hospital costs were converted from longitudinal patient charges. A multivariate mixed effects model compared adjusted costs and mortality between groups.
resultsSuccessful propensity score matching was performed with 699 infants (peritoneal drainage, n = 101; peritoneal drainage followed by laparotomy, n = 172; and laparotomy, n = 426). Average adjusted cost for peritoneal drainage followed by laparotomy was $398,173 (95% confidence interval [CI]: 287,784-550,907), which was more than for peritoneal drainage ($276,076 [95% CI: 196,238-388,394]; P = .004) and similar to laparotomy ($341,911 [95% CI: 251,304-465,186]; P = .08). Adjusted mortality was highest after peritoneal drainage (56% [95% CI: 34-75]) versus peritoneal drainage followed by laparotomy (35% [95% CI: 19-56]; P = .01) and laparotomy (29% [95% CI: 19-56]; P < .001). Mortality for peritoneal drainage was similar to laparotomy.
conclusionsPropensity score-matched analysis of surgical NEC treatment found that peritoneal drainage followed by laparotomy was associated with decreased mortality compared with peritoneal drainage alone but at significantly increased costs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.