ArticleForensic science, medicine, and pathology2007
Increasing amplification success of forensic DNA samples using multiple displacement amplification.
Article in Forensic science, medicine, and pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Investigative strategy for the forensic detection of sperm traces.Forensic science, medicine, and pathology · 2009Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple displacement amplification (MDA) is capable of amplifying nanogram template amounts of DNA with high accuracy to generate micrograms of representative product. Although MDA is able to amplify small template amounts (<100 pg), increased levels of preferential amplification and allelic dropout are observed. The use of molecular crowders (polyethylene glycol 400) can decrease the amplification bias and increase amplification success. We describe the use of standard and crowded MDA on low-concentration casework samples originating from blood, semen, saliva, hair, and trace DNA. While standard MDA produced no significant increases in STR genotyping success, the use of crowded MDA yielded an average increase of 15% in the number of alleles, with a significant decrease in the amplification bias, resulting in clearer, more-complete profiles from forensically relevant samples.
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Registered trials
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