Evidence map›Paper›PMID 25869138›Full record

ArticleThe Journal of biological chemistry2015

Spy1 Protein Mediates Phosphorylation and Degradation of SCG10 Protein in Axonal Degeneration.

Yonghua Liu, Youhua Wang, Ying Chen, Xiaohong Li, Jiao Yang, Yang Liu, Aiguo Shen

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Axon degeneration: context defines distinct pathways.Current opinion in neurobiology · 2016
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yonghua LiuFrom the Medical College, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target.
Youhua WangFrom the Medical College, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target.
Ying ChenFrom the Medical College, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target.
Xiaohong LiFrom the Medical College, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target.
Jiao YangFrom the Medical College, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target.
Yang LiuFrom the Medical College, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target.
Aiguo ShenFrom the Medical College, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Jiangsu Province Key Laboratory of Neuroregeneration, and Co-innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China shen_aiguo@yahoo.com.
Nanyang Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Axon loss is a destructive consequence of a wide range of neurological diseases without a clearly defined mechanism. Recent data demonstrate that SCG10 is a novel axonal maintenance factor and that rapid SCG10 loss after injury requires JNK activity; how JNK induces degradation of SCG10 is not well known. Here we showed that SCG10 was a binding partner of Spy1, a Speedy/RINGO family protein, which participated in cellular response to sciatic nerve injury. During the early stage of axonal injury, Spy1 expression was inversely correlated with SCG10. Spy1 mediated SCG10 phosphorylation and degradation partly in a JNK-dependent manner. Inhibition of Spy1 attenuated SCG10 phosphorylation and delayed injury-induced axonal degeneration. Taken together, these data suggest that Spy1 is an important regulator of SCG10 and can be targeted in future axo-protective therapeutics.

Indexed as

AnimalsAxonsBrainCarrier ProteinsCell Cycle ProteinsDNA, ComplementaryGene LibraryHEK293 CellsHumansMAP Kinase Kinase 4Membrane ProteinsMicroscopy, Phase-ContrastMicrotubule ProteinsPhosphorylationPlasmidsProtein Interaction MappingCarrier ProteinsCell Cycle ProteinsDNA, ComplementaryMAP Kinase Kinase 4Membrane ProteinsMicrotubule ProteinsSPDYA protein, humanSpdya protein, ratStathminSTMN2 protein, humanStmn2 protein, rataxonaxon lossJNKmolecular cell biologyneurite outgrowthneurodegenerative diseasephosphorylationprotein phosphorylationprotein-protein interactionprotein stabilitySCG10Spy1

Identifiers

PMID25869138
PMCPMC4447963
OpenAlexW1734190181

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.