ArticleSchizophrenia research2015
Stimulus train duration but not attention moderates γ-band entrainment abnormalities in schizophrenia.
Article in Schizophrenia research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Effects of N-Methyl-d-Aspartate Receptor Antagonists on Gamma-Band Activity During Auditory Stimulation Compared With Electro/Magneto-encephalographic Data in Schizophrenia and Early-Stage Psychosis: A Systematic Review and Perspective.Schizophrenia bulletin · 2024Pooled it
- Gamma-Band Auditory Steady-State Response and Attention: A Systemic Review.Brain sciences · 2024Review
- Auditory Steady-State Responses in Schizophrenia: An Updated Meta-Analysis.Brain sciences · 2023Review
- Double dissociation between P300 components and task switch error type in healthy but not psychosis participants.Schizophrenia research · 2023Article
- Influence of inter-stimulus interval on 40-Hz auditory steady-state response in patients with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- Cortical connectomic mediations on gamma band synchronization in schizophrenia.Translational psychiatry · 2023Article
- Aberrant attentional modulation of the auditory steady state response (ASSR) is related to auditory hallucination severity in the first-episode schizophrenia-spectrum.Journal of psychiatric research · 2022Article
- Neural network dynamics underlying gamma synchronization deficits in schizophrenia.Progress in neuro-psychopharmacology & biological psychiatry · 2021Article
- Hierarchical Pathways from Sensory Processing to Cognitive, Clinical, and Functional Impairments in Schizophrenia.Schizophrenia bulletin · 2021Article
- A distributed frontotemporal network underlies gamma-band synchronization impairments in schizophrenia patients.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- A roadmap for development of neuro-oscillations as translational biomarkers for treatment development in neuropsychopharmacology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Review
- Divisive gain modulation enables flexible and rapid entrainment in a neocortical microcircuit model.Journal of neurophysiology · 2020Article
- Cortical Microcircuit Mechanisms of Mismatch Negativity and Its Underlying Subcomponents.Frontiers in neural circuits · 2020Review
- Auditory steady-state EEG response across the schizo-bipolar spectrum.Schizophrenia research · 2019Article
- Identifying auditory cortex encoding abnormalities in schizophrenia: The utility of low-frequency versus 40 Hz steady-state measures.Psychophysiology · 2018Article
- Defects of Gamma Oscillations in Auditory Steady-State Evoked Potential of Schizophrenia.Shanghai archives of psychiatry · 2018Article
- Stereological Assessments of Neuronal Pathology in Auditory Cortex in Schizophrenia.Frontiers in neuroanatomy · 2017Review
- Phase-locking index and power of 40-Hz auditory steady-state response are not related to major personality trait dimensions.Experimental brain research · 2016Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Electroencephalographic (EEG) studies of auditory steady-state responses (aSSRs) non-invasively probe gamma-band (40-Hz) oscillatory capacity in sensory cortex with high signal-to-noise ratio. Consistent reports of reduced 40-Hz aSSRs in persons with schizophrenia (SZ) indicate its potential as an efficient biomarker for the disease, but studies have been limited to passive or indirect listening contexts with stereotypically short (500ms) stimulus trains. An inability to modulate sensorineural processing in accord with behavioral goals or within the sensory environmental context may represent a fundamental deficit in SZ, but whether and how this deficit relates to reduced aSSRs is unknown. We systematically varied stimulus duration and attentional contexts to further mature the 40-Hz aSSR as biomarker for future translational or mechanistic studies. Eighteen SZ and 18 healthy subjects (H) were presented binaural pure-tones with or without sinusoidal amplitude modulation at 40-Hz. Stimulus duration (500-ms or 1500-ms) and attention (via a button press task) were varied across 4 separate blocks. Evoked potentials recorded with dense-array EEGs were analyzed in the time-frequency domain. SZ displayed reduced 40-Hz aSSRs to typical stimulation parameters, replicating previous findings. In H, aSSRs were reduced when stimuli were presented in longer trains and were slightly enhanced by attention. Only the former modulation was impaired in SZ and correlated with sensory discrimination performance. Thus, gamma-band aSSRs are modulated by both attentional and stimulus duration contexts, but only modulations related to physical stimulus properties are abnormal in SZ, supporting its status as a biomarker of psychotic perceptual disturbance involving non-attentional sensori-cortical circuits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.