ArticleNature communications2015
Molecular development of chondrichthyan claspers and the evolution of copulatory organs.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 50 citations in OpenAlex.
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- Mineralized Cartilage and Bone-Like Tissues in Chondrichthyans Offer Potential Insights Into the Evolution and Development of Mineralized Tissues in the Vertebrate Endoskeleton.Frontiers in genetics · 2021Review
- Evolution of Matrix Gla and Bone Gla Protein Genes in Jawed Vertebrates.Frontiers in genetics · 2021Article
- The intraspecific diversity of tooth morphology in the large-spotted catshark Scyliorhinus stellaris: insights into the ontogenetic cues driving sexual dimorphism.Journal of anatomy · 2020Article
- Growth trajectories of prenatal embryos of the deep-sea shark Chlamydoselachus anguineus (Chondrichthyes).Journal of fish biology · 2020Article
- Discrete Hedgehog Factor Expression and Action in the Developing Phallus.International journal of molecular sciences · 2020Article
- Similarity of morphological composition and developmental patterning in paired fins of the elephant shark.Scientific reports · 2017Article
- Differing roles for sur-2/MED23 in C. elegans and C. briggsae vulval development.Development genes and evolution · 2017Article
- The role ofEvoDevo · 2017Article
- Developing an ancient epithelial appendage: FGF signalling regulates early tail denticle formation in sharks.EvoDevo · 2017Article
- HoxD expression in the fin-fold compartment of basal gnathostomes and implications for paired appendage evolution.Scientific reports · 2016Article
- Molecular mechanisms underlying the exceptional adaptations of batoid fins.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The earliest known vertebrate copulatory organs are claspers, paired penis-like structures that are associated with evolution of internal fertilization and viviparity in Devonian placoderms. Today, only male chondrichthyans possess claspers, which extend from posterior pelvic fins and function as intromittent organs. Here we report that clasper development from pelvic fins of male skates is controlled by hormonal regulation of the Sonic hedgehog (Shh) pathway. We show that Shh signalling is necessary for male clasper development and is sufficient to induce clasper cartilages in females. Androgen receptor (AR) controls the male-specific pattern of Shh in pelvic fins by regulation of Hand2. We identify an androgen response element (ARE) in the Hand2 locus and present biochemical evidence that AR can directly bind the Hand2 ARE. Together, our results suggest that the genetic circuit for appendage development evolved an androgen regulatory input, which prolonged signalling activity and drove clasper skeletogenesis in male fins.
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