ArticleInternational journal of cancer2015
Transcriptional regulation of tenascin-W by TGF-beta signaling in the bone metastatic niche of breast cancer cells.
Article in International journal of cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 32 citations in OpenAlex.
- Exploring bone-tumor interactions through 3DJournal of bone oncology · 2025Review
- Review
- The extracellular matrix of hematopoietic stem cell niches.Advanced drug delivery reviews · 2022Review
- Revisiting the Tenascins: Exploitable as Cancer Targets?Frontiers in oncology · 2022Review
- Genome variation in colorectal cancer patient with liver metastasis measured by whole-exome sequencing.Journal of gastrointestinal oncology · 2021Article
- Latent TGF-β Activation Is a Hallmark of the Tenascin Family.Frontiers in immunology · 2021Article
- Causal network perturbations for instance-specific analysis of single cell and disease samples.Bioinformatics (Oxford, England) · 2020Article
- Tenascin-W Is a Novel Stromal Marker in Biliary Tract Cancers.Frontiers in immunology · 2020Article
- Regulation of Osteosclerosis by Inoculated Cd133JBMR plus · 2019Article
- The extracellular matrix in tumor progression and metastasis.Clinical & experimental metastasis · 2019Review
- New Advances in the Study of Bone Tumors: A Lesson From the 3D Environment.Frontiers in physiology · 2019Article
- Article
- The Expression and Possible Functions of Tenascin-W During Development and Disease.Frontiers in cell and developmental biology · 2019Review
- Pre-clinical Models for Studying the Interaction Between Mesenchymal Stromal Cells and Cancer Cells and the Induction of Stemness.Frontiers in oncology · 2019Review
- Article
- Cancer Stem Cells: Emergent Nature of Tumor Emergency.Frontiers in genetics · 2018Article
- CR6-interacting factor 1 inhibits invasiveness by suppressing TGF-β-mediated epithelial-mesenchymal transition in hepatocellular carcinoma.Oncotarget · 2017Article
- Wenshen Zhuanggu formula effectively suppresses breast cancer bone metastases in a mouse Xenograft model.Acta pharmacologica Sinica · 2017Article
- In Vitro Co-Culture Models of Breast Cancer Metastatic Progression towards Bone.International journal of molecular sciences · 2016Review
- Matricellular proteins as regulators of cancer metastasis to bone.Matrix biology : journal of the International Society for Matrix BiologyReview
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tenascin-W is a matricellular protein with a dynamically changing expression pattern in development and disease. In adults, tenascin-W is mostly restricted to stem cell niches, and is also expressed in the stroma of solid cancers. Here, we analyzed its expression in the bone microenvironment of breast cancer metastasis. Osteoblasts were isolated from tumor-free or tumor-bearing bones of mice injected with MDA-MB231-1833 breast cancer cells. We found a fourfold upregulation of tenascin-W in the osteoblast population of tumor-bearing mice compared to healthy mice, indicating that tenascin-W is supplied by the bone metastatic niche. Transwell and co-culture studies showed that human bone marrow stromal cells (BMSCs) express tenascin-W protein after exposure to factors secreted by MDA-MB231-1833 breast cancer cells. To study tenascin-W gene regulation, we identified and analyzed the tenascin-W promoter as well as three evolutionary conserved regions in the first intron. 5'RACE analysis of mRNA from human breast cancer, glioblastoma and bone tissue showed a single tenascin-W transcript with a transcription start site at a noncoding first exon followed by exon 2 containing the ATG translation start. Site-directed mutagenesis of a SMAD4-binding element in proximity of the TATA box strongly impaired promoter activity. TGFβ1 induced tenascin-W expression in human BMSCs through activation of the TGFβ1 receptor ALK5, while glucocorticoids were inhibitory. Our experiments show that tenascin-W acts as a niche component for breast cancer metastasis to bone by supporting cell migration and cell proliferation of the cancer cells.
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