SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2015
Glutathione S-transferase T1 and M1 null genotypes and Parkinson's disease risk: evidence from an updated meta-analysis.
Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Association Between Blood-Brain Barrier Disruption and Gut Microbiota Dysbiosis in Parkinson's Disease.Cellular and molecular neurobiology · 2026Review
- Article
- Glutathione S-transferases Control astrocyte activation and neuronal health during neuroinflammation.Frontiers in molecular biosciences · 2022Article
- Association of variants in microRNA with Parkinson's disease in Chinese Han population.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutathione S-transferase T1 and M1 (GSTT1 and GSTM1) have been reported to be associated with Parkinson's disease (PD). However, the results of these previous studies were inconsistent. The reported studies were conducted from 1990 to 2014 by searching PubMed. The total Odds Ratio and 95 % Confidence Interval were calculated and analyzed by Review Manager 5.1 and STATA 12. We also did subgroup analysis of ethnicity, publication year and sample size of total cases. Sensitivity analysis and publication bias were also done to evaluate the credibility of the results. A total of 3753 PD patients and 5636 controls from 19 case-control studies were identified. Overall, no association was observed (OR 1.01, 95 % CI 0.99-1.21, P = 0.07) between GSTM1 null genotype and PD. There was significant association in Caucasians when subgroup analysis of ethnicity was performed, and the same conclusion was observed in European and UK. And it was also in publication year of 1995-1999 and in sample size of total cases of <90 and 91-181. However, there was no significant association between GSTT1 null genotype and PD risk in this meta-analysis. Publication bias was negligible and the overall results were stable by sensitivity analysis. A slight increase of PD risk was detected in the meta-analysis of GSTM1 null genotype in subgroup analysis of ethnicity, publication year and sample size of total cases. However, short of statistical significance was detected for GSTT1 null genotype.
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