ArticleNutrients2015
Differential acute effects of selenomethionine and sodium selenite on the severity of colitis.
Article in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Navigating the microbial maze: unraveling the connection between gut microbiome and pediatric kidney and urinary tract disease.Pediatric nephrology (Berlin, Germany) · 2025Review
- Selenium, Immunity, and Inflammatory Bowel Disease.Nutrients · 2024Review
- Article
- Nutritional Support: The Use of Antioxidants in Inflammatory Bowel Disease.International journal of molecular sciences · 2024Review
- The Trace Element Selenium Is Important for Redox Signaling in Phorbol Ester-Differentiated THP-1 Macrophages.International journal of molecular sciences · 2021Article
- Antioxidant Therapy in Inflammatory Bowel Diseases.Antioxidants (Basel, Switzerland) · 2021Review
- Selenium-Containing Amino Acids Protect Dextran Sulfate Sodium-Induced Colitis via Ameliorating Oxidative Stress and Intestinal Inflammation.Journal of inflammation research · 2021Article
- Absorption and Distribution of Selenium Following Oral Administration of Selenium-Enriched Bifidobacterium longum DD98, Selenized Yeast, or Sodium Selenite in Rats.Biological trace element research · 2020Article
- Compositional alterations of gut microbiota in children with primary nephrotic syndrome after initial therapy.BMC nephrology · 2019Article
- Micronutrient Deficiencies in Medical and Surgical Inpatients.Journal of clinical medicine · 2019Review
- Treatment of Caenorhabditis elegans with Small Selenium Species Enhances Antioxidant Defense Systems.Molecular nutrition & food research · 2019Article
- Roles for selenium and selenoprotein P in the development, progression, and prevention of intestinal disease.Free radical biology & medicine · 2018Review
- New Insights into the Role of Trace Elements in IBD.BioMed research international · 2018Review
- Dietary Selenium and Human Health.Nutrients · 2016Article
- Selenium and inflammatory bowel disease.American journal of physiology. Gastrointestinal and liver physiology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The European population is only suboptimally supplied with the essential trace element selenium. Such a selenium status is supposed to worsen colitis while colitis-suppressive effects were observed with adequate or supplemented amounts of both organic selenomethionine (SeMet) and inorganic sodium selenite. In order to better understand the effect of these selenocompounds on colitis development we examined colonic phenotypes of mice fed supplemented diets before the onset of colitis or during the acute phase. Colitis was induced by treating mice with 1% dextran sulfate sodium (DSS) for seven days. The selenium-enriched diets were either provided directly after weaning (long-term) or were given to mice with a suboptimal selenium status after DSS withdrawal (short-term). While long-term selenium supplementation had no effect on colitis development, short-term selenite supplementation, however, resulted in a more severe colitis. Colonic selenoprotein expression was maximized in all selenium-supplemented groups independent of the selenocompound or intervention time. This indicates that the short-term selenite effect appears to be independent from colonic selenoprotein expression. In conclusion, a selenite supplementation during acute colitis has no health benefits but may even aggravate the course of disease.
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Registered trials
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