Evidence map›Paper›PMID 25867815›Full record

ArticleThe Journal of clinical endocrinology and metabolism2015

Abnormal Skeletal Strength and Microarchitecture in Women With Celiac Disease.

Emily M Stein, Halley Rogers, Alexa Leib, Donald J McMahon, Polly Young, Kyle Nishiyama, X Edward Guo, Suzanne Lewis, Peter H Green, Elizabeth Shane

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Tools Used to Measure the Physical State of Women with Celiac Disease: A Review with a Systematic Approach.International journal of environmental research and public health · 2020
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Observational
  6. Review
  7. Review
  8. Celiac disease and bone.Archives of endocrinology and metabolism · 2022
    Review
  9. Review
  10. Bone Fragility in Gastrointestinal Disorders.International journal of molecular sciences · 2022
    Review
  11. Article
  12. Review
  13. Article
  14. Management of bone health in patients with celiac disease: Practical guide for clinicians.Canadian family physician Medecin de famille canadien · 2018
    Review
  15. Canadian family physician Medecin de famille canadien · 2018
    Review
  16. Bone and Celiac Disease.Current osteoporosis reports · 2016
    Review
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Emily M SteinDivisions of Endocrinology and Gastroenterology (E.M.S., H.R., A.L., D.J.M., P.Y., K.N.,S.L., P.H.G., E.S.), Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032; and Bone Bioengineering Laboratory (X.E.G.), Department of Biomedical Engineering, Columbia University, New York, New York 10027.
Halley RogersDivisions of Endocrinology and Gastroenterology (E.M.S., H.R., A.L., D.J.M., P.Y., K.N.,S.L., P.H.G., E.S.), Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032; and Bone Bioengineering Laboratory (X.E.G.), Department of Biomedical Engineering, Columbia University, New York, New York 10027.
Alexa LeibDivisions of Endocrinology and Gastroenterology (E.M.S., H.R., A.L., D.J.M., P.Y., K.N.,S.L., P.H.G., E.S.), Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032; and Bone Bioengineering Laboratory (X.E.G.), Department of Biomedical Engineering, Columbia University, New York, New York 10027.
Donald J McMahonDivisions of Endocrinology and Gastroenterology (E.M.S., H.R., A.L., D.J.M., P.Y., K.N.,S.L., P.H.G., E.S.), Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032; and Bone Bioengineering Laboratory (X.E.G.), Department of Biomedical Engineering, Columbia University, New York, New York 10027.
Polly YoungDivisions of Endocrinology and Gastroenterology (E.M.S., H.R., A.L., D.J.M., P.Y., K.N.,S.L., P.H.G., E.S.), Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032; and Bone Bioengineering Laboratory (X.E.G.), Department of Biomedical Engineering, Columbia University, New York, New York 10027.
Kyle NishiyamaDivisions of Endocrinology and Gastroenterology (E.M.S., H.R., A.L., D.J.M., P.Y., K.N.,S.L., P.H.G., E.S.), Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032; and Bone Bioengineering Laboratory (X.E.G.), Department of Biomedical Engineering, Columbia University, New York, New York 10027.
X Edward GuoDivisions of Endocrinology and Gastroenterology (E.M.S., H.R., A.L., D.J.M., P.Y., K.N.,S.L., P.H.G., E.S.), Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032; and Bone Bioengineering Laboratory (X.E.G.), Department of Biomedical Engineering, Columbia University, New York, New York 10027.
Suzanne LewisDivisions of Endocrinology and Gastroenterology (E.M.S., H.R., A.L., D.J.M., P.Y., K.N.,S.L., P.H.G., E.S.), Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032; and Bone Bioengineering Laboratory (X.E.G.), Department of Biomedical Engineering, Columbia University, New York, New York 10027.
Peter H GreenDivisions of Endocrinology and Gastroenterology (E.M.S., H.R., A.L., D.J.M., P.Y., K.N.,S.L., P.H.G., E.S.), Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032; and Bone Bioengineering Laboratory (X.E.G.), Department of Biomedical Engineering, Columbia University, New York, New York 10027.
Elizabeth ShaneDivisions of Endocrinology and Gastroenterology (E.M.S., H.R., A.L., D.J.M., P.Y., K.N.,S.L., P.H.G., E.S.), Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032; and Bone Bioengineering Laboratory (X.E.G.), Department of Biomedical Engineering, Columbia University, New York, New York 10027.
Columbia University · US

Funding

Micro-Mechanical Modeling of Trabecular BoneR01AR051376 · NIAMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GUO, X. EDWARD · 2006 to 2015
$3.2M
Idiopathic Osteoporosis in Premenopausal WomenK24AR052665 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHANE, ELIZABETH J · 2005 to 2014
$1.8M
NIAMS NIH HHS 2K24 AR052665NIAMS NIH HHS K24 AR052665NIAMS NIH HHS R01 AR051376
6 · The paper itself

Abstract

contextOsteoporosis is often a presenting sign of celiac disease (CD). Whether skeletal fragility in CD is associated with microarchitectural abnormalities is not known.

objectiveThe objective of the study was to evaluate microarchitecture and biomechanical properties of bone in CD.

designThis was a case-control study.

settingThe study was conducted at a university hospital outpatient facility. PATIENTS: Patients included premenopausal women with newly diagnosed CD (n = 33) and healthy controls (n = 33).

main outcome measuresAreal bone mineral density by dual-energy x-ray absorptiometry was measured as was trabecular and cortical volumetric bone mineral density (vBMD) and microarchitecture by high-resolution peripheral computed tomography of the distal radius and tibia. Whole-bone stiffness estimated by finite element analysis. PTH, 25-hydroxyvitamin D, and bone turnover markers were also measured.

resultsGroups had similar age, race, and body mass index. Both groups had sufficient 25-hydroxyvitamin D and normal calcium and PTH. Areal bone mineral density was lower in CD. By high-resolution peripheral computed tomography, CD had lower trabecular vBMD, fewer, more widely, and irregularly spaced trabeculae at both the radius and tibia (8%-33%). At the tibia, they also had lower total density (8%) and thinner cortices (10%). Whole-bone stiffness and failure load were lower (11%-21%) in CD at both sites. Biomechanical deficits were associated with trabecular abnormalities.

conclusionsWomen with CD had abnormal vBMD and microarchitecture at both the radius and tibia. Trabecular bone was preferentially affected. These deficits were associated with lower estimates of skeletal strength. These findings suggest a potential structural mechanism for skeletal fragility in CD and support further research into the pathogenesis of fracture in this population.

Indexed as

Bone DensityCeliac DiseaseAbsorptiometry, PhotonAdultBone and BonesCalciumCase-Control StudiesCompressive StrengthFemaleFractures, BoneHumansMiddle AgedTomography, X-Ray ComputedVitamin DYoung Adult25-hydroxyvitamin DCalciumVitamin D

Identifiers

PMID25867815
PMCPMC4454795
OpenAlexW2141286670

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.