Evidence map›Paper›PMID 25867808›Full record

ArticleThe Journal of clinical endocrinology and metabolism2015

A Patient With a Thyrotropin-Secreting Microadenoma and Resistance to Thyroid Hormone (P453T).

Xiaochun Teng, Ting Jin, Gregory A Brent, Anhua Wu, Weiping Teng, Zhongyan Shan

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.

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  10. Approach to the Patient With Raised Thyroid Hormones and Nonsuppressed TSH.The Journal of clinical endocrinology and metabolism · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Xiaochun TengDepartment of Endocrinology and Metabolism (X.T., T.J., W.T., Z.S.), Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang 110001, People's Republic of China; Molecular Endocrinology Laboratory (G.A.B.), Veterans Affairs Greater Los Angeles Healthcare System, Departments of Medicine and Physiology, UCLA David Geffen School of Medicine, Los Angeles, California 90073; and Department of Neurosurgery (A.W.), The First Affiliated Hospital of China Medical University, Shenyang 110001, People's Republic of China.
Ting JinDepartment of Endocrinology and Metabolism (X.T., T.J., W.T., Z.S.), Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang 110001, People's Republic of China; Molecular Endocrinology Laboratory (G.A.B.), Veterans Affairs Greater Los Angeles Healthcare System, Departments of Medicine and Physiology, UCLA David Geffen School of Medicine, Los Angeles, California 90073; and Department of Neurosurgery (A.W.), The First Affiliated Hospital of China Medical University, Shenyang 110001, People's Republic of China.
Gregory A BrentDepartment of Endocrinology and Metabolism (X.T., T.J., W.T., Z.S.), Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang 110001, People's Republic of China; Molecular Endocrinology Laboratory (G.A.B.), Veterans Affairs Greater Los Angeles Healthcare System, Departments of Medicine and Physiology, UCLA David Geffen School of Medicine, Los Angeles, California 90073; and Department of Neurosurgery (A.W.), The First Affiliated Hospital of China Medical University, Shenyang 110001, People's Republic of China.
Anhua WuDepartment of Endocrinology and Metabolism (X.T., T.J., W.T., Z.S.), Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang 110001, People's Republic of China; Molecular Endocrinology Laboratory (G.A.B.), Veterans Affairs Greater Los Angeles Healthcare System, Departments of Medicine and Physiology, UCLA David Geffen School of Medicine, Los Angeles, California 90073; and Department of Neurosurgery (A.W.), The First Affiliated Hospital of China Medical University, Shenyang 110001, People's Republic of China.
Weiping TengDepartment of Endocrinology and Metabolism (X.T., T.J., W.T., Z.S.), Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang 110001, People's Republic of China; Molecular Endocrinology Laboratory (G.A.B.), Veterans Affairs Greater Los Angeles Healthcare System, Departments of Medicine and Physiology, UCLA David Geffen School of Medicine, Los Angeles, California 90073; and Department of Neurosurgery (A.W.), The First Affiliated Hospital of China Medical University, Shenyang 110001, People's Republic of China.
Zhongyan ShanDepartment of Endocrinology and Metabolism (X.T., T.J., W.T., Z.S.), Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang 110001, People's Republic of China; Molecular Endocrinology Laboratory (G.A.B.), Veterans Affairs Greater Los Angeles Healthcare System, Departments of Medicine and Physiology, UCLA David Geffen School of Medicine, Los Angeles, California 90073; and Department of Neurosurgery (A.W.), The First Affiliated Hospital of China Medical University, Shenyang 110001, People's Republic of China.
China Medical University · CNFirst Hospital of China Medical University · CNVA Greater Los Angeles Healthcare System · US

Funding

Thyroid Hormone Receptor Isoform-Specific ActionsR01DK098576 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BRENT, GREGORY A · 2014 to 2017
$1.3M
Thyroid Hormone and Retinoic Acid Regulation of Gene ExpressionI01BX001966 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI BRENT, GREGORY A · 2014 to 2025
–
BLRD VA I01 BX001966NIDDK NIH HHS R01 DK098576
6 · The paper itself

Abstract

contextResistance to thyroid hormone (RTH) β is due to mutations in the β-isoform of the thyroid hormone receptor (TR). TSH-secreting adenomas (TSHomas) are presumed to represent clonal expansion and have been reported to contain TRβ gene mutations. Mice with a knock-in mutation in the TRβ gene spontaneously develop TSHomas, although as yet no patient has been reported to have both a TSHoma and RTHβ.

objectiveWe investigated a 12-year-old girl with elevated serum T4 concentration, inappropriately high TSH levels, and a pituitary adenoma. DESIGN AND

interventionClinical, biochemical, and radiological assessments were performed at baseline and after a transsphenoidal pituitary adenomectomy.

resultsThe patient's laboratory results included: TSH, 21.12 mIU/L (0.35-4.94 mIU/L); free T3, 14.25 pmol/L (2.63-5.7 pmol/L); free T4, 28.79 pmol/L (9.01-19.05 pmol/L); serum glycoprotein hormone alpha-subunit (α-GSU), 0.32 ng/ml (0.22-0.39 ng/ml); and α-GSU/TSH, 0.15. Thyroid radioiodine uptake was increased by 94.4% at 24 hours. A T3 suppression test showed incomplete suppression of the serum TSH concentration and blunted response of the peripheral thyroid hormone markers. The sequence of TRβ exons confirmed a P453T mutation in the TRβ gene. Pituitary magnetic resonance imaging revealed a microadenoma in the left side of the pituitary. The patient underwent transsphenoidal pituitary adenomectomy. Histologically, the tumor stained positively for TSH-β, human Chorionic Gonadotropin alpha (HCG-α), GH, prolactin, and ACTH. After removal of the tumor, the patient's thyroid function improved significantly, and she experienced the onset of menarche and an increase in linear growth as well.

conclusionsThis patient with RTHβ had a TSHoma consistent with previous findings linking somatic TRβ mutations to TSHomas.

Indexed as

AdenomaAmino Acid SubstitutionChildFemaleHumansHyperpituitarismParaneoplastic Endocrine SyndromesPituitary NeoplasmsProlineThreonineThyroid Hormone Receptors betaThyroid Hormone Resistance SyndromeThyrotropinProlineThreonineThyroid Hormone Receptors betaThyrotropin

Identifiers

PMID25867808
PMCPMC5393528
OpenAlexW2104882724

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.