ArticleInternational journal of molecular sciences2015
Antimicrobial action of water-soluble β-chitosan against clinical multi-drug resistant bacteria.
Article in International journal of molecular sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 54 citations in OpenAlex.
- Enhanced Wound Healing With β-Chitosan-Zinc Oxide Nanoparticles: Insights From Zebrafish Models.Cureus · 2024Article
- Ameliorative Effects ofMolecules (Basel, Switzerland) · 2024Article
- Anti-COVID-19 Credentials of Chitosan Composites and Derivatives: Future Scope?Antibiotics (Basel, Switzerland) · 2023Review
- Hybrid Bio-Based Silicone Coatings with Anti-adhesive Properties.Materials (Basel, Switzerland) · 2023Article
- Constitutive chitosanase from Bacillus thuringiensis B-387 and its potential for preparation of antimicrobial chitooligomers.World journal of microbiology & biotechnology · 2022Article
- Clinically relevant materials & applications inspired by food technologies.EBioMedicine · 2022Review
- Preparation and Antimicrobial Activity of Chitosan and Its Derivatives: A Concise Review.Molecules (Basel, Switzerland) · 2021Review
- Antimicrobial Contribution of Chitosan Surface-Modified Nanoliposomes Combined with Colistin against Sensitive and Colistin-Resistant ClinicalPharmaceutics · 2020Article
- Facile Synthesis of Antimicrobial Aloe Vera-"Smart" Triiodide-PVP Biomaterials.Biomimetics (Basel, Switzerland) · 2020Article
- Vaginal siRNA delivery: overview on novel delivery approaches.Drug delivery and translational research · 2020Review
- Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action.International journal of molecular sciences · 2019Review
- "Smart" Triiodide Compounds: Does Halogen Bonding Influence Antimicrobial Activities?Pathogens (Basel, Switzerland) · 2019Article
- Review
- Extraction of chitosan and its oligomers from shrimp shell waste, their characterization and antimicrobial effect.Veterinary world · 2017Article
- Novel chitosan/diclofenac coatings on medical grade stainless steel for hip replacement applications.Scientific reports · 2016Article
- Development of a New Monomer for the Synthesis of Intrinsic Antimicrobial Polymers with Enhanced Material Properties.International journal of molecular sciences · 2015Article
- Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications.Marine drugs · 2015Review
- A Multiple siRNA-Based Anti-HIV/SHIV Microbicide Shows Protection in Both In Vitro and In Vivo Models.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, the number of patients infected by drug-resistant pathogenic microbes has increased remarkably worldwide, and a number of studies have reported new antibiotics from natural sources. Among them, chitosan, with a high molecular weight and α-conformation, exhibits potent antimicrobial activity, but useful applications as an antibiotic are limited by its cytotoxicity and insolubility at physiological pH. In the present study, the antibacterial activity of low molecular weight water-soluble (LMWS) α-chitosan (α1k, α5k, and α10k with molecular masses of 1, 5, and 10 kDa, respectively) and β-chitosan (β1k, β5k, and β10k) was compared using a range of pathogenic bacteria containing drug-resistant bacteria isolated from patients at different pH. Interestingly, β5k and β10k exhibited potent antibacterial activity, even at pH 7.4, whereas only α10k was effective at pH 7.4. The active target of β-chitosan is the bacterial membrane, where the leakage of calcein is induced in artificial PE/PG vesicles, bacterial mimetic membrane. Moreover, scanning electron microscopy showed that they caused significant morphological changes on the bacterial surfaces. An in vivo study utilizing a bacteria-infected mouse model found that LMWS β-chitosan could be used as a candidate in anti-infective or wound healing therapeutic applications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.