ArticleInternational journal of environmental research and public health2015
Relationship between the concentrations of heavy metals and bioelements in aging men with metabolic syndrome.
Article in International journal of environmental research and public health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 4 syntheses or guidelines pooled it, 133 citations in OpenAlex.
- Re-thinking the link between exposure to mercury and blood pressure.Archives of toxicology · 2025Pooled it
- Mercury Exposure and Risk of Type 2 Diabetes: A Systematic Review and Meta-Analysis.International journal of clinical practice · 2022Pooled it
- Crosstalk of Magnesium and Serum Lipids in Dyslipidemia and Associated Disorders: A Systematic Review.Nutrients · 2021Pooled it
- Selenium exposure and the risk of type 2 diabetes: a systematic review and meta-analysis.European journal of epidemiology · 2018Pooled it
- Associations of Whole Blood Minerals and Trace Elements with Body Composition in Overweight and Obese Patients: A Retrospective Cross-Sectional Study.Biological trace element research · 2026Article
- Metabolic and cardiovascular profiles in diabetes type 2: a comparative analysis of zinc homeostasis and blood pressure-a single center case-control study.Scientific reports · 2026Article
- Combined Effects of Metals and PFAS Exposure on Prevalent Diabetes.Journal of xenobiotics · 2026Article
- Manganese: biology, physiology and role in disease.Cell discovery · 2026Review
- Associations of occupational exposure to multiple heavy metals and metabolic syndrome among metal foundry workers: a cross‑sectional study.BMC endocrine disorders · 2026Article
- Beneficial Role of Zinc in Metabolic Syndrome: Understanding the Underlying Pathophysiological Mechanisms.Current medicinal chemistry · 2026Review
- Association Between Serum Cobalt and Manganese Levels with Insulin Resistance in Overweight and Obese Mexican Women.Healthcare (Basel, Switzerland) · 2025Article
- Article
- Dietary Manganese Modulates Microbiota and Intestinal N-Acylethanolamines in a Sex-Specific Manner in Mice With Diet-Induced Obesity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Impact of blood lead and manganese levels on metabolic dysfunction-associated steatotic liver disease prevalence: insights from NHANES (2017-2020).BMC gastroenterology · 2025Article
- Multi-Omics Assessment of Puff Volume-Mediated Salivary Biomarkers of Metal Exposure and Oxidative Injury Associated with Electronic Nicotine Delivery Systems.Environmental health perspectives · 2025Article
- Biochemical study of the risk of diabetes, prediabetic and insulin resistance in car painters and its association with mercury exposure: a retrospective case-control study.Toxicology research · 2024Article
- Association of heavy metals and bio-elements blood level with metabolic syndrome: a systematic review and meta-analysis of observational studies.Journal of diabetes and metabolic disorders · 2024Review
- Effects of Various Heavy Metal Exposures on Insulin Resistance in Non-diabetic Populations: Interpretability Analysis from Machine Learning Modeling Perspective.Biological trace element research · 2024Article
- Machine learning uncovers manganese as a key nutrient associated with reduced risk of steatotic liver disease.Liver international : official journal of the International Association for the Study of the Liver · 2024Article
- Association Between Circulating Zinc Levels and Risk Factors of Metabolic Syndrome: Insights from a Bi-directional Mendelian Randomization Analysis and Cross-Sectional Study.Biological trace element research · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heavy metals may exacerbate metabolic syndrome (MS) but abnormal serum concentrations of bioelements may also co-exist with MS. The primary aim of the study was to assess the relationship of blood heavy metal and bioelement concentrations and MS, in men aged 50-75 years. Heavy metals-lead (Pb), cadmium (Cd), mercury (Hg), arsenic (As), tungsten (W), Macroelements-magnesium (Mg) and calcium (Ca), and microelements-iron (Fe), zinc (Zn) copper (Cu), chromium (Cr), molybdenum (Mo), selenium (Se) and manganese (Mn), body mass index (BMI), waist to hip ratio (WHR), abdominal circumference (AC) and blood pressure (BP), total cholesterol (TCh), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride (TG), fasting plasma glucose (FPG), insulin, and Homeostasis Model Assessment-Insulin resistance (HOMA-IR). The men with MS showed statistically significant higher Zn and lower Mg concentrations. Those with diabetes had higher Ca concentration and lower Mg concentration. Cr and Mn concentrations were significantly higher in obese men. The participants with hypertension had lower Mg concentration. We found statistically significant positive correlations (W-TCh, W-LDL, Mg-TCh, Mg-LDL, Ca-TCh, Ca-LDL, Ca-insulin, Ca-HOMAR-IR, Zn-TG, Zn-insulin, Zn-HOMA-IR, Cu-BP systolic, Mn-BMI, Mn-AC, Mn-WHR, Mn-insulin, Mn-HOMA-IR, Se-TCh, Se-LDL, Se-TG, Se-insulin, Se-HOMA-IR, Cr-TCh, Cr-HDL, Cr-LDL, Cr-TG) and negative correlations (Cd-insulin, Hg-WHR, W-insulin, W-HOMA-IR, Mg-BMI, Mg-AC, Mg-WHR, Mg-BP systolic, Mo-insulin, Mn-HDL). Tungsten may contribute to lipid disorders. Magnesium appears to play the protective role in the occurrence of metabolic disorders. Microelements Mn, Cr and Se may intensify MS.
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