Evidence map›Paper›PMID 25867197›Full record

ArticleStem cells and development2015

Mesenchymal Stem Cell Exosomes Induce Proliferation and Migration of Normal and Chronic Wound Fibroblasts, and Enhance Angiogenesis In Vitro.

Arsalan Shabbir, Audrey Cox, Luis Rodriguez-Menocal, Marcela Salgado, Evangelos Van Badiavas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells and development, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 402 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
402citing papers in PubMed, 7 pooled it
39.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

402 citing papers in PubMed, 7 syntheses or guidelines pooled it, 719 citations in OpenAlex.

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  19. Clinical Applications of Extracellular Vesicles: Promises and Pitfalls.International journal of molecular sciences · 2026
    Review
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342 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Arsalan ShabbirDepartment of Dermatology and Cutaneous Surgery, Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine , Miami, Florida.
Audrey CoxDepartment of Dermatology and Cutaneous Surgery, Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine , Miami, Florida.
Luis Rodriguez-MenocalDepartment of Dermatology and Cutaneous Surgery, Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine , Miami, Florida.
Marcela SalgadoDepartment of Dermatology and Cutaneous Surgery, Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine , Miami, Florida.
Evangelos Van BadiavasDepartment of Dermatology and Cutaneous Surgery, Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine , Miami, Florida.
University of Miami · US

Funding

Bone Marrow Stem Cells and the Microenvironment of Chronic WoundsR01AG027874 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BADIAVAS, EVANGELOS VAN · 2007 to 2011
$1.6M
NIA NIH HHS R01AG027874
6 · The paper itself

Abstract

Although chronic wounds are common and continue to be a major cause of morbidity and mortality, treatments for these conditions are lacking and often ineffective. A large body of evidence exists demonstrating the therapeutic potential of mesenchymal stem cells (MSCs) for repair and regeneration of damaged tissue, including acceleration of cutaneous wound healing. However, the exact mechanisms of wound healing mediated by MSCs are unclear. In this study, we examined the role of MSC exosomes in wound healing. We found that MSC exosomes ranged from 30 to 100-nm in diameter and internalization of MSC exosomes resulted in a dose-dependent enhancement of proliferation and migration of fibroblasts derived from normal donors and chronic wound patients. Uptake of MSC exosomes by human umbilical vein endothelial cells also resulted in dose-dependent increases of tube formation by endothelial cells. MSC exosomes were found to activate several signaling pathways important in wound healing (Akt, ERK, and STAT3) and induce the expression of a number of growth factors [hepatocyte growth factor (HGF), insulin-like growth factor-1 (IGF1), nerve growth factor (NGF), and stromal-derived growth factor-1 (SDF1)]. These findings represent a promising opportunity to gain insight into how MSCs may mediate wound healing.

Indexed as

AgedCell MovementCell ProliferationCells, CulturedChemokine CXCL12Coculture TechniquesDiabetes MellitusExosomesExtracellular Signal-Regulated MAP KinasesFibroblastsHepatocyte Growth FactorHumansHuman Umbilical Vein Endothelial CellsInsulin-Like Growth Factor IMaleMAP Kinase Signaling SystemChemokine CXCL12CXCL12 protein, humanExtracellular Signal-Regulated MAP KinasesHepatocyte Growth FactorHGF protein, humanIGF1 protein, humanInsulin-Like Growth Factor INerve Growth FactorNGF protein, humanProto-Oncogene Proteins c-aktSTAT3 protein, humanSTAT3 Transcription Factor

Identifiers

PMID25867197
PMCPMC4499790
OpenAlexW1612482630

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.