Evidence map›Paper›PMID 25867175›Full record

ArticlePloS one2015

Predictors of in vitro fertilization outcomes in women with highest follicle-stimulating hormone levels ≥ 12 IU/L: a prospective cohort study.

Lina N Huang, Sunny H Jun, Nathalie Drubach, Michael H Dahan

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Impact of Various Parameters as Predictors of The Success Rate ofInternational journal of fertility & sterility · 2022
    Review
  4. Article
  5. Roles of kisspeptin in IVF/ICSI-treated infertile women and in human granulosa cells.Experimental biology and medicine (Maywood, N.J.) · 2021
    Article
  6. Article
  7. Egg Quality and Pregnancy Outcome in Young Infertile Women with Diminished Ovarian Reserve.Medical science monitor : international medical journal of experimental and clinical research · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Lina N HuangDepartment of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
Sunny H JunDepartment of Obstetrics and Gynecology, Stanford University, Stanford, California, United States of America.
Nathalie DrubachDepartment of Obstetrics and Gynecology, Stanford University, Stanford, California, United States of America.
Michael H DahanDepartment of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
McGill University · CAStanford University · US

Funding

WOMEN'S REPRODUCTIVE HEALTH RESEARCH CAREER DEVELOPMENTK12HD001249 · NICHD · STANFORD UNIVERSITY · PI BEREK, JONATHAN S · 1998 to 2008
$3.3M
NICHD NIH HHS K12 HD001249
6 · The paper itself

Abstract

objectiveThe purpose of this study is to evaluate factors predictive of outcomes in women with highest follicle-stimulating hormone (FSH) levels ≥ 12 IU/L on basal testing, undergoing in vitro fertilization (IVF).

methodsA prospective cohort study was conducted at Stanford University Hospital in the Reproductive Endocrinology and Infertility Center for 12 months. Women age 21 to 43 undergoing IVF with highest FSH levels on baseline testing were included. Donor/Recipient and frozen embryo cycles were excluded from this study. Prognostic factors evaluated in association with clinical pregnancy rates were type of infertility diagnosis and IVF stimulation parameters.

resultsThe current study found that factors associated with clinical pregnancy were: increased number of mature follicles on the day of triggering, number of oocytes retrieved, number of Metaphase II oocytes if intracytoplasmic sperm injection was done, and number of embryos developed 24 hours after retrieval.

conclusionsOur findings suggest that it would be beneficial for women with increased FSH levels to attempt a cycle of IVF. Results of ovarian stimulation, especially embryo quantity appear to be the best predictors of IVF outcomes and those can only be obtained from a cycle of IVF. Therefore, increased basal FSH levels should not discourage women from attempting a cycle of IVF.

Indexed as

Fertilization in VitroPregnancy RateAdultFemaleFollicle Stimulating HormoneHumansOvarian ReservePregnancyProspective StudiesFollicle Stimulating Hormone

Identifiers

PMID25867175
PMCPMC4395083
OpenAlexW1973949420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.