ArticleEuropean journal of immunology2015
Pemphigus is associated with KIR3DL2 expression levels and provides evidence that KIR3DL2 may bind HLA-A3 and A11 in vivo.
Article in European journal of immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- High-resolution KIR and HLA genotyping in three Chinese ethnic minorities reveals distinct origins.HLA · 2024Article
- Correlation between human leukocyte antigen ligands and killer cell immunoglobulin-like receptors in aplastic anemia patients from Shaanxi Han.Immunogenetics · 2023Article
- Immunogenomics of Killer Cell Immunoglobulin-Like Receptor (KIR) and HLA Class I: Coevolution and Consequences for Human Health.The journal of allergy and clinical immunology. In practice · 2022Article
- Article
- Current research status of HLA in immune-related diseases.Immunity, inflammation and disease · 2021Review
- High-Resolution Analysis Identifies High Frequency ofFrontiers in immunology · 2021Article
- Variation in genes implicated in B-cell development and antibody production affects susceptibility to pemphigus.Immunology · 2021Article
- Beyond the HLA polymorphism: A complex pattern of genetic susceptibility to pemphigus.Genetics and molecular biology · 2020Article
- Fluctuating and Geographically Specific Selection Characterize Rapid Evolution of the HumanFrontiers in immunology · 2019Article
- Association of Functional Polymorphisms of KIR3DL1/DS1 With Behçet's Disease.Frontiers in immunology · 2019Article
- Screening the full leucocyte receptor complex genomic region revealed associations with pemphigus that might be explained by gene regulation.Immunology · 2019Article
- Article
- High-Resolution Genetic and Phenotypic Analysis of KIR2DL1 Alleles and Their Association with Pre-Eclampsia.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- A genomic perspective on HLA evolution.Immunogenetics · 2018Review
- Sparking Fire Under the Skin? Answers From the Association of Complement Genes With Pemphigus Foliaceus.Frontiers in immunology · 2018Article
- α3-Deletion Isoform of HLA-A11 Modulates Cytotoxicity of NK Cells: Correlations with HIV-1 Infection of Cells.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Deciphering the killer-cell immunoglobulin-like receptor system at super-resolution for natural killer and T-cell biology.Immunology · 2017Review
- Can we make a better match or mismatch with KIR genotyping?Hematology. American Society of Hematology. Education Program · 2016Review
- Differential gene expression levels might explain association of LAIR2 polymorphisms with pemphigus.Human genetics · 2016Article
- The Impact of KIR Polymorphism on the Risk of Developing Cancer: Not as Strong as Imagined?Frontiers in genetics · 2016Review
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Authors and funding
8 authors at 4 institutions in 2 countries.
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Abstract
Although HLA-A3 and A11 have been reported to be ligands for KIR3DL2, evidence for any in vivo relevance of this interaction is still missing. To explore the functional importance of KIR3DL2 allelic variation, we analyzed the autoimmune disease pemphigus foliaceus, previously associated (lower risk) with activating KIR genes. KIR3DL2*001 was increased in patients (odds ratio (OR) = 2.04; p = 0.007). The risk was higher for the presence of both KIR3DL2*001 and HLA-A3 or A11 (OR = 3.76, p = 0.013), providing the first evidence that HLA-A3 and A11 may interact with KIR3DL2 in vivo. The nonsynonymous single nucleotide polymorphism 1190T (rs3745902) was associated with protection (OR = 0.52, p = 0.018). This SNP results in a threonine-to-methionine substitution. Individuals who have methionine in this position exhibit a lower percentage of KIR3DL2-positive natural killer (NK) cells and also lower intensity of KIR3DL2 on expressing natural killer cells; additionally, we show that the expression of KIR3DL2 is independent of other killer cell immunoglobulin-like receptors. Pemphigus foliaceus is a very unique complex disease strongly associated with immune-related genes. It is the only autoimmune disease known to be endemic, showing a strong correlation with environmental factors. Our data demonstrate that this relatively unknown autoimmune disease may facilitate understanding of the molecular mechanisms of KIR3DL2 ligand recognition.
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