ArticleCancer science2015
High levels of DJ-1 protein and isoelectric point 6.3 isoform in sera of breast cancer patients.
Article in Cancer science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Article
- Article
- DJ-1 promotes osteosarcoma progression through activating CDK4/RB/E2F1 signaling pathway.Frontiers in oncology · 2022Article
- Article
- DJ‑1 is a new prognostic marker and predicts chemotherapy efficacy in colorectal cancer.Oncology reports · 2020Article
- DJ‑1 promotes cell proliferation and tumor metastasis in esophageal squamous cell carcinoma via the Wnt/β‑catenin signaling pathway.International journal of oncology · 2020Article
- Novel Insights into PARK7 (DJ-1), a Potential Anti-Cancer Therapeutic Target, and Implications for Cancer Progression.Journal of clinical medicine · 2020Review
- Role of DJ-1 in Immune and Inflammatory Diseases.Frontiers in immunology · 2020Review
- Review
- The clinical significance of DJ-1 and HE4 in patients with endometrial cancer.Journal of clinical laboratory analysis · 2018Article
- Novel association of DJ-1 with HER3 potentiates HER3 activation and signaling in cancer.Oncotarget · 2016Article
- DJ-1 Expression in Cervical Carcinoma and its Effects on Cell Viability and Apoptosis.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Diagnostic and prognostic value of serum thioredoxin and DJ-1 in non-small cell lung carcinoma patients.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
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Authors and funding
19 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In patients with cancer and Parkinson's disease, the DJ-1 protein may be secreted into the serum during the impaired response of the underlying cell-protective mechanisms. In order to determine the clinical significance of DJ-1 protein in the sera of breast cancer patients, we examined blood samples from a breast cancer group (n = 180) and a non-cancerous control group (n = 300). Higher levels of DJ-1 were detected in the breast cancer group (mean level, 42.7 ng/mL) than the control group (28.3 ng/mL) by ELISA (P = 0.019). Higher DJ-1 levels were significantly associated with advanced clinical grade, according to the TNM classification, negative hormone receptor status, and high Ki-67 labeling index, of biopsied materials; samples showed low DJ-1 protein expression despite upregulated DJ-1 mRNA. DJ-1 isoforms could be detected clearly in 17 blood samples (from 11 breast cancer patients, and 6 non-cancerous controls) by 2-D gel electrophoresis and immunoblot analysis. The isoform at the pI of 6.3 showed the highest intensity in all 11 cancer cases. Conversely, in the 6 non-cancerous cases, isoforms other than the pI 6.3 isoform were highly expressed, and there was a significant difference in the isoform pattern between breast cancer cases and controls (P = 0.00025). These data indicate that high levels of DJ-1, probably of isoform at pI 6.3, is a candidate serum marker of breast cancer.
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