ArticleeLife2015
Natural genetic variation in Arabidopsis thaliana defense metabolism genes modulates field fitness.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 161 citations in OpenAlex.
- Sulfur as a central integrator of plant-microbe interactions: from nutrient cycling to immune signalling and microbiome assembly.Journal of experimental botany · 2026Review
- Guns in rosettes: The Arabidopsis chemical weapons arsenal.Plant physiology · 2025Review
- An effluent pump family distributed across plant commensal bacteria conditions host- and organ-specific glucosinolate detoxification.Nature communications · 2025Article
- Article
- 6Pgdh polymorphism in wild bulb mite populations: prevalence, environmental correlates and life history trade-offs.Experimental & applied acarology · 2024Article
- Complementing model species with model clades.The Plant cell · 2024Review
- Tomato root specialized metabolites evolved through gene duplication and regulatory divergence within a biosynthetic gene cluster.Science advances · 2024Article
- Genome-wide association studies identify loci controlling specialized seed metabolites in Arabidopsis.Plant physiology · 2024Article
- A large-effect fitness trade-off across environments is explained by a single mutation affecting cold acclimation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Genetic basis and selection of glyceollin elicitation in wild soybean.Frontiers in plant science · 2024Article
- A persistent major mutation in canonical jasmonate signaling is embedded in an herbivory-elicited gene network.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Artificial selection reveals complex genetic architecture of shoot branching and its response to nitrate supply in Arabidopsis.PLoS genetics · 2023Article
- Allyl isothiocyanate and 6-(methylsulfinyl) hexyl isothiocyanate contents vary among wild and cultivated wasabi (Breeding science · 2023Article
- Phenotypic Variation in Phytochemical Defense of Trembling Aspen in Western North America: Genetics, Development, and Geography.Journal of chemical ecology · 2023Article
- Plant-herbivore interactions: Experimental demonstration of genetic variability in plant-plant signalling.Evolutionary applications · 2023Article
- Genetic variation underlying differential ammonium and nitrate responses in Arabidopsis thaliana.The Plant cell · 2022Article
- Transposable elements maintain genome-wide heterozygosity in inbred populations.Nature communications · 2022Article
- High-energy-level metabolism and transport occur at the transition from closed to open flowers.Plant physiology · 2022Article
- Genome-wide association mapping within a localPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- High-throughput measurement of plant fitness traits with an object detection method using Faster R-CNN.The New phytologist · 2022Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural populations persist in complex environments, where biotic stressors, such as pathogen and insect communities, fluctuate temporally and spatially. These shifting biotic pressures generate heterogeneous selective forces that can maintain standing natural variation within a species. To directly test if genes containing causal variation for the Arabidopsis thaliana defensive compounds, glucosinolates (GSL) control field fitness and are therefore subject to natural selection, we conducted a multi-year field trial using lines that vary in only specific causal genes. Interestingly, we found that variation in these naturally polymorphic GSL genes affected fitness in each of our environments but the pattern fluctuated such that highly fit genotypes in one trial displayed lower fitness in another and that no GSL genotype or genotypes consistently out-performed the others. This was true both across locations and within the same location across years. These results indicate that environmental heterogeneity may contribute to the maintenance of GSL variation observed within Arabidopsis thaliana.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.