ArticleeLife2015
Assessing long-distance RNA sequence connectivity via RNA-templated DNA-DNA ligation.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Enhancing cardiomyocyte reprogramming efficiency by targeting cellular senescence is mediated via Rb1 gene.Stem cell research & therapy · 2025Article
- Circular RNAs in Cardiovascular Physiopathology: From Molecular Mechanisms to Therapeutic Opportunities.International journal of molecular sciences · 2025Review
- Computational approaches and challenges in the analysis of circRNA data.BMC genomics · 2024Review
- Recent advances in cancer fusion transcript detection.Briefings in bioinformatics · 2023Review
- A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain.Nature communications · 2021Article
- Review
- Plasmid-based gap-repair recombineered transgenes reveal a central role for introns in mutually exclusive alternative splicing in Down Syndrome Cell Adhesion Molecule exon 4.Nucleic acids research · 2019Article
- Getting the Entire Message: Progress in Isoform Sequencing.Frontiers in genetics · 2019Review
- Single-cell isoform RNA sequencing characterizes isoforms in thousands of cerebellar cells.Nature biotechnology · 2018Article
- Molecular functions and specific roles of circRNAs in the cardiovascular system.Non-coding RNA research · 2018Review
- Molecular roles and function of circular RNAs in eukaryotic cells.Cellular and molecular life sciences : CMLS · 2018Review
- Microfluidic isoform sequencing shows widespread splicing coordination in the human transcriptome.Genome research · 2018Article
- The determinants of alternative RNA splicing in human cells.Molecular genetics and genomics : MGG · 2017Review
- Detecting circular RNAs: bioinformatic and experimental challenges.Nature reviews. Genetics · 2016Review
- Sensitive and specific miRNA detection method using SplintR Ligase.Nucleic acids research · 2016Article
- Circular RNAs: analysis, expression and potential functions.Development (Cambridge, England) · 2016Review
- Determining exon connectivity in complex mRNAs by nanopore sequencing.Genome biology · 2015Article
- Splice and sequence.Nature methods · 2015Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Many RNAs, including pre-mRNAs and long non-coding RNAs, can be thousands of nucleotides long and undergo complex post-transcriptional processing. Multiple sites of alternative splicing within a single gene exponentially increase the number of possible spliced isoforms, with most human genes currently estimated to express at least ten. To understand the mechanisms underlying these complex isoform expression patterns, methods are needed that faithfully maintain long-range exon connectivity information in individual RNA molecules. In this study, we describe SeqZip, a methodology that uses RNA-templated DNA-DNA ligation to retain and compress connectivity between distant sequences within single RNA molecules. Using this assay, we test proposed coordination between distant sites of alternative exon utilization in mouse Fn1, and we characterize the extraordinary exon diversity of Drosophila melanogaster Dscam1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.