ArticlePloS one2015
The pbrB gene encodes a laccase required for DHN-melanin synthesis in conidia of Talaromyces (Penicillium) marneffei.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- The multifaceted physiological roles of fungal laccases.Communications biology · 2026Review
- Talaromyces sayulitensis as a Potential Bioremediation Agent for Metformin.Applied biochemistry and biotechnology · 2025Article
- Regulation of melanin production in fungi.Frontiers in fungal biology · 2025Review
- Exploring the Agricultural Applications of Microbial Melanin.Microorganisms · 2024Review
- Article
- Unraveling the dynamic transcriptomic changes during the dimorphic transition ofFrontiers in microbiology · 2024Article
- Structure-function studies of a novel laccase-like multicopper oxidase from Thermothelomyces thermophila provide insights into its biological role.Acta crystallographica. Section D, Structural biology · 2023Article
- Fungi as a source of eumelanin: current understanding and prospects.Journal of industrial microbiology & biotechnology · 2023Article
- New insights and advances on pyomelanin production: from microbial synthesis to applications.Journal of industrial microbiology & biotechnology · 2022Review
- Key thermally dimorphic fungal pathogens: shaping host immunity.Open biology · 2022Review
- Review
- Fungal quinones: diversity, producers, and applications of quinones from Aspergillus, Penicillium, Talaromyces, Fusarium, and Arthrinium.Applied microbiology and biotechnology · 2021Review
- Laccase Properties, Physiological Functions, and Evolution.International journal of molecular sciences · 2020Review
- Copper and Melanin Play a Role inFrontiers in microbiology · 2020Article
- Proteomic Analysis ofFrontiers in microbiology · 2020Article
- Article
- A Single-Nucleotide Deletion in the Transcription Factor GeneFrontiers in microbiology · 2017Article
- Expression and characterization of a Talaromyces marneffei active phospholipase B expressed in a Pichia pastoris expression system.Emerging microbes & infections · 2016Article
- Role of laccase in the virulence of Talaromyces marneffei: A common link between AIDS-related fungal pathogens?Virulence · 2016Article
- Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Talaromyces marneffei (Basionym: Penicillium marneffei) is a significant opportunistic fungal pathogen in patients infected with human immunodeficiency virus in Southeast Asia. T. marneffei cells have been shown to become melanized in vivo. Melanins are pigment biopolymers which act as a non-specific protectant against various stressors and which play an important role during virulence in fungi. The synthesis of the two most commonly found melanins in fungi, the eumelanin DOPA-melanin and the allomelanin DHN-melanin, requires the action of laccase enzymes. The T. marneffei genome encodes a number of laccases and this study describes the characterization of one of these, pbrB, during growth and development. A strain carrying a PbrB-GFP fusion shows that pbrB is expressed at high levels during asexual development (conidiation) but not in cells growing vegetatively. The pbrB gene is required for the synthesis of DHN-melanin in conidia and when deleted results in brown pigmented conidia, in contrast to the green conidia of the wild type.
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