Evidence map›Paper›PMID 25866834›Full record

ArticleJournal of endocrinology, diabetes & obesity

Thyroid Hormone Signaling in Muscle Development, Repair and Metabolism.

Jang-Won Lee, Nam-Ho Kim, Anna Milanesi

Abstract read
In one paragraph

Article in Journal of endocrinology, diabetes & obesity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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  15. Association of thyroid status prior to transition to end-stage renal disease with early dialysis mortality.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jang-Won LeeDepartment of Neurosurgery, Cedars-Sinai Medical Center, USA.
Nam-Ho KimDepartment of Neurosurgery, Cedars-Sinai Medical Center, USA.
Anna MilanesiDepartment of Medicine, Division of Endocrinology, VA Greater Los Angeles Healthcare System, USA.

Funding

Thyroid Hormone Receptor Isoforms in Skeletal MuscleK08DK097295 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MILANESI, ANNA · 2013 to 2016
$648k
NIDDK NIH HHS K08 DK097295
6 · The paper itself

Abstract

Skeletal muscle is a plastic organ made by highly specialize fibers with specific and different structure, function and metabolism. Skeletal muscle fibers can adapt, change, recover/regenerate after injury in response to various stimulators including hormones. Thyroid hormones are important players in the homeostasis of several tissue including skeletal muscle and their genomic action mostly depend on the tissue T3 bioavailability and on the distribution of the thyroid receptor isoforms which act as transcription factors and are modulated by T3. Changing in contractile and metabolic proprieties of the muscle fibers has been described in experimental models of hyper and hypothyroidism. Animal models with disruption of thyroid hormone signaling showed different and specific skeletal muscle phenotypes. By focusing on thyroid hormone signaling in skeletal muscle homeostasis, we review T3 specific action on skeletal muscle development, postnatal growth, function and metabolism.

Indexed as

Muscle developmentMuscle functionMuscle metabolismMuscle repairThyroid hormone

Identifiers

PMID25866834
PMCPMC4390064

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.