Trial reportBioMed research international2015
Patients with intolerance reactions to total knee replacement: combined assessment of allergy diagnostics, periprosthetic histology, and peri-implant cytokine expression pattern.
Trial report in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- Titanium and Other Metal Hypersensitivity Diagnosed by MELISA® Test: Follow-Up Study.BioMed research international · 2021Trial
- Hypoallergenic Knee Implant Usage and Clinical Outcomes: Are They Safe and Effective?Arthroplasty today · 2024Article
- Understanding immune-mediated cobalt/chromium allergy to orthopaedic implants: a meta-synthetic review.Arthroplasty (London, England) · 2024Review
- Metal hypersensitivity in hip, knee and spine surgery.Postepy dermatologii i alergologii · 2023Review
- Hypersensitivity and lymphocyte activation after total hip arthroplasty.Orthopadie (Heidelberg, Germany) · 2023Review
- Poor Correlation Among Metal Hypersensitivity Testing Modalities and Inferior Patient-Reported Outcomes After Primary and Revision Total Knee Arthroplasties.Arthroplasty today · 2022Article
- The effect of Nickel hypersensitivity on the outcome of total knee arthroplasty and the value of skin patch testing: a systematic review.Arthroplasty (London, England) · 2022Review
- Synchrotron-based characterization of arthroprosthetic CoCrMo particles in human bone marrow.Journal of materials science. Materials in medicine · 2022Article
- Metallic Implants Used in Lumbar Interbody Fusion.Materials (Basel, Switzerland) · 2022Review
- Serum Indicators of Oxidative Damage from Embedded Metal Fragments in a Rat Model.Oxidative medicine and cellular longevity · 2022Article
- Metal allergy in primary and revision total knee arthroplasty : a scoping review and evidence-based practical approach.Bone & joint open · 2021Article
- Metal Hypersensitivity in Joint Arthroplasty.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2021Review
- Increased risk of eczema after joint replacement: A population-based retrospective cohort study.Medicine · 2019Observational
- A case series of cementless revision total knee arthroplasty in patients with benzoyl peroxide allergy.International orthopaedics · 2019Article
- Review
- Trunnion Corrosion in Total Hip Arthroplasty-Basic Concepts.The Orthopedic clinics of North America · 2019Review
- Exploring the Incidence, Implications, and Relevance of Metal Allergy to Orthopaedic Surgeons.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2019Article
- Allergy to Surgical Implants.Clinical reviews in allergy & immunology · 2019Review
- CD3+ lymphocytosis in the peri-implant membrane of 222 loosened joint endoprostheses depends on the tribological pairing.Acta orthopaedica · 2017Article
- Metal wear-induced pseudotumour following an endoprosthetic knee replacement for Ewing sarcoma.Skeletal radiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We performed a combined approach to identify suspected allergy to knee arthroplasty (TKR): patch test (PT), lymphocyte transformation test (LTT), histopathology (overall grading; T- and B-lymphocytes, macrophages, and neutrophils), and semiquantitative Real-time-PCR-based periprosthetic inflammatory mediator analysis (IFNγ, TNFα, IL1-β, IL-2, IL-6, IL-8, IL-10, IL17, and TGFβ). We analyzed 25 TKR patients with yet unexplained complications like pain, effusion, and reduced range of motion. They consisted of 20 patients with proven metal sensitization (11 with PT reactions; 9 with only LTT reactivity). Control specimens were from 5 complicated TKR patients without metal sensitization, 12 OA patients before arthroplasty, and 8 PT patients without arthroplasty. Lymphocytic infiltrates were seen and fibrotic (Type IV membrane) tissue response was most frequent in the metal sensitive patients, for example, in 81% of the PT positive patients. The latter also had marked periprosthetic IFNγ expression. 8/9 patients with revision surgery using Ti-coated/oxinium based implants reported symptom relief. Our findings demonstrate that combining allergy diagnostics with histopathology and periprosthetic cytokine assessment could allow us to design better diagnostic strategies.
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