ArticleJundishapur journal of natural pharmaceutical products2015
Effect of royal jelly on formalin induced-inflammation in rat hind paw.
Article in Jundishapur journal of natural pharmaceutical products, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- Combined anti-inflammatory and laxative effect of mango kernels-based effervescent suppositories loaded with (multi)metallic nanoparticles synthesized using ash of plantain peels and gel of Aloe vera.Drug delivery and translational research · 2026Article
- Comparative UPLC/MSScientific reports · 2026Article
- Effects of royal jelly on ovary cancer cells proliferation and apoptosis.Medical oncology (Northwood, London, England) · 2025Article
- Anti-Inflammatory, Antinociceptive, and Antipyretic Potential of Methanol Extract ofInternational journal of inflammation · 2025Article
- Pollen and bee bread expressed highest anti-inflammatory activities among bee products in chronic inflammation: an experimental study with cotton pellet granuloma in rats.Inflammopharmacology · 2023Article
- Molecular Insights into Royal Jelly Anti-Inflammatory Properties and Related Diseases.Life (Basel, Switzerland) · 2023Review
- Comparative antihyperglycemic, analgesic and anti-inflammatory potential of ethanolic aerial root extracts ofHeliyon · 2023Article
- Supplementation of syringic acid-richHeliyon · 2023Article
- Further evidence to support acute and chronic anti-inflammatory effects ofResearch in pharmaceutical sciences · 2022Article
- Anti-Inflammatory and Analgesic Activity of Methanolic Root Extract ofJournal of inflammation research · 2022Article
- Anti-Inflammatory Medicinal Plants of Bangladesh-A Pharmacological Evaluation.Frontiers in pharmacology · 2022Review
- Possible therapeutic effect of royal jelly on endometriotic lesion size, pain sensitivity, and neurotrophic factors in a rat model of endometriosis.Physiological reports · 2021Article
- Effect of ethanolic extract ofResearch in pharmaceutical sciences · 2021Article
- Montelukast potentiates the antiinflammatory effect of NSAIDs in the rat paw formalin model and simultaneously minimizes the risk of gastric damage.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021Article
- Anti-Inflammatory Activity ofTheScientificWorldJournal · 2021Article
- The effect of royal jelly on the growth of breast cancer in mice.Oncology letters · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRoyal Jelly (RJ), a food item secreted by worker honeybees, is a mixture that contains protein, glucose, lipid, vitamins, and minerals; it is widely used as a commercial medical product. Previous studies have shown that RJ has a number of physiological effects, such as anti-inflammatory, antitumor, antiallergic and antioxidant activities.
objectivesIn the present study, the anti-inflammatory properties of RJ were investigated in formalin-induced rat paw edema. MATERIALS AND
methodsIn this study, 30 male Wistar albino rats were divided into five equal groups (n = 6) as follows: test groups received different doses (25, 50 and 100 mg/kg, ip) of RJ and a negative control group received normal saline (5 mL/kg) and a positive control group received aspirin (300 mg/kg, i.p). Edema was induced on the right hind paw of the rat by a subplantar injection of 100 µL of formalin (2.5%) after 30 minutes. Paw edema was measured in the rats received the drugs, saline and aspirin before and after the formalin injection during 5 hours, using a plethysmometer.
resultsThe results showed that RJ has a dose-dependent anti-inflammatory effect and the highest anti-inflammatory effect was observed in the doses of 50 and 100 mg/kg.
conclusionsRoyal jelly has potent anti-inflammatory effects compared to aspirin and it could be used in the treatment of inflammation. However, further studies are required to determine the active components in RJ responsible for this effect and its mechanism of action.
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