ArticleEvidence-based complementary and alternative medicine : eCAM2015
Bidens pilosa Formulation Improves Blood Homeostasis and β -Cell Function in Men: A Pilot Study.
Article in Evidence-based complementary and alternative medicine : eCAM, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- A comprehensive review of antimalarial medicinal plants used by Tanzanians.Pharmaceutical biology · 2024Pooled it
- Mexican Plants Involved in Glucose Homeostasis and Body Weight Control: Systematic Review.Nutrients · 2023Pooled it
- MiyakoCurrent issues in molecular biology · 2025Article
- Vasorelaxant effects of biochemical constituents of various medicinal plants and their benefits in diabetes.World journal of diabetes · 2024Review
- Ethnomedicinal plants used for malaria treatment in Rukungiri District, Western Uganda.Tropical medicine and health · 2023Article
- Medicinal plants used for treatment of malaria by indigenous communities of Tororo District, Eastern Uganda.Tropical medicine and health · 2023Article
- Review
- A review on the potential of underutilized BlackjackHeliyon · 2022Review
- Toxicity study ofJournal of traditional and complementary medicine · 2020Article
- The complete chloroplast genome of the invasive and Cd-hyperaccumulator herbMitochondrial DNA. Part B, Resources · 2020Article
- Article
- Histochemistry and immunolocalisation of glucokinin in antidiabetic plants used in traditional Mexican medicine.European journal of histochemistry : EJH · 2017Article
- Bidens pilosa and its active compound inhibit adipogenesis and lipid accumulation via down-modulation of the C/EBP and PPARγ pathways.Scientific reports · 2016Article
- Plant-Derived Compounds Targeting Pancreatic Beta Cells for the Treatment of Diabetes.Evidence-based complementary and alternative medicine : eCAM · 2015Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
B. pilosa has long been purported to have antidiabetes activity, but despite the advancement in phytochemistry and animal models of diabetes, no human clinical trials have been conducted to date. Here, we evaluated the effect of a B. pilosa formulation on fasting blood glucose (FBG), fasting serum insulin, and glycosylated hemoglobin A1c (HbA1c) in diabetic subjects. The B. pilosa formulation reduced the level of FBG and HbA1c in diabetics but increased fasting serum insulin in healthy subjects. Moreover, combination of B. pilosa formulation with antidiabetic drugs had better glycemic control in diabetics. The homeostatic model assessment (HOMA) data suggested that the antidiabetic activity of this formulation was via improvement of β-cell function. We also tested the safety of the B. pilosa formulation in healthy subjects and observed no obvious side effects. We conclude that B. pilosa has potential as an antidiabetes treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.