Evidence map›Paper›PMID 25866469›Full record

ArticleInternational journal of mass spectrometry2015

Protein Expression by Human Pulmonary Artery Smooth Muscle Cells Containing a

Chunxiang Yao, Jun Yu, Linda Taylor, Peter Polgar, Mark E McComb, Catherine E Costello

Abstract read
In one paragraph

Article in International journal of mass spectrometry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Journal of the American Heart Association · 2024
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Proteomic analysis of pulmonary arterial hypertension.Therapeutic advances in chronic disease · 2021
    Review
  9. Article
  10. Osteocytes control myeloid cell proliferation and differentiation through Gsα-dependent and -independent mechanisms.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Chunxiang YaoCenter for Biomedical Mass Spectrometry, Boston University School of Medicine, 670 Albany St., Boston, MA 02118 USA.
Jun YuDepartment of Biochemistry, Boston University School of Medicine, Boston, MA 02118 USA.
Linda TaylorDepartment of Biochemistry, Boston University School of Medicine, Boston, MA 02118 USA.
Peter PolgarDepartment of Biochemistry, Boston University School of Medicine, Boston, MA 02118 USA.
Mark E McCombCenter for Biomedical Mass Spectrometry, Boston University School of Medicine, 670 Albany St., Boston, MA 02118 USA.
Catherine E CostelloCenter for Biomedical Mass Spectrometry, Boston University School of Medicine, 670 Albany St., Boston, MA 02118 USA ; Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118 USA.
Boston University · US

Funding

Mass Spectrometry Resource for Biology and MedicineP41GM104603 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COSTELLO, CATHERINE E. · 2012 to 2017
$10.4M
REGULATION OF PROSTAGLANDIN SYNTHESIS BY LUNG CELLSR01HL025776 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI POLGAR, PETER RUDOLPH · 1985 to 2013
$4.6M
MALDI-TOF/TOF MS TO SUPPORT BIOMEDICAL RESEARCHS10OD010724 · OD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COSTELLO, CATHERINE E. · 2012 to 2012
$590k
LTQ MASS SPECTROMETER: STRUCTURAL BIOLOGYS10RR020946 · NCRR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ZAIA, JOSEPH · 2006 to 2006
$497k
NCRR NIH HHS S10 RR020946NHLBI NIH HHS HHSN268201000031CNHLBI NIH HHS R01 HL025776NIGMS NIH HHS P41 GM104603NIH HHS S10 OD010724
6 · The paper itself

Abstract

Pulmonary arterial hypertension (PAH) is a disease characterized by increased pulmonary vascular resistance and remodeling. Increase in the population of vascular smooth muscle cells is among the key events contributing to the remodeling. Endothelin-1 (ET-1), a potent vasoconstrictor, is linked to the etiology and progression of PAH. Here we analyze changes in protein expressions in response to ET-1 in pulmonary arterial smooth muscle cells (PASMC) from a healthy Control (non-PAH) and a PAH subject presenting a bone morphogenetic protein type II receptor (

Indexed as

BMPR2endothelin-1label-free quantitationproteomic mass spectrometrypulmonary arterial hypertensionsignal transduction

Identifiers

PMID25866469
PMCPMC4387548
OpenAlexW2045789824

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.