Evidence map›Paper›PMID 25866160›Full record

ArticleStem cell reports2015

Human embryonic and induced pluripotent stem cell research trends: complementation and diversification of the field.

Sabine Kobold, Anke Guhr, Andreas Kurtz, Peter Löser

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sabine KoboldRobert Koch Institute, D-13353 Berlin, Germany.
Anke GuhrRobert Koch Institute, D-13353 Berlin, Germany.
Andreas KurtzBerlin-Brandenburg Center for Regenerative Therapies, D-13353 Berlin, Germany; Seoul National University, Seoul 151-742, Korea. Electronic address: andreas.kurtz@charite.de.
Peter LöserRobert Koch Institute, D-13353 Berlin, Germany. Electronic address: loeserp@rki.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Research in human induced pluripotent stem cells (hiPSCs) is rapidly developing and there are expectations that this research may obviate the need to use human embryonic stem cells (hESCs), the ethics of which has been a subject of controversy for more than 15 years. In this study, we investigated approximately 3,400 original research papers that reported an experimental use of these types of human pluripotent stem cells (hPSCs) and were published from 2008 to 2013. We found that research into both cell types was conducted independently and further expanded, accompanied by a growing intersection of both research fields. Moreover, an in-depth analysis of papers that reported the use of both cell types indicates that hESCs are still being used as a "gold standard," but in a declining proportion of publications. Instead, the expanding research field is diversifying and hESC and hiPSC lines are increasingly being used in more independent research and application areas.

Indexed as

Stem Cell ResearchDatabases, FactualEmbryonic Stem CellsHumansInduced Pluripotent Stem CellsPublishing

Identifiers

PMID25866160
PMCPMC4437486

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.