ArticleAging cell2015
Paternal age and telomere length in twins: the germ stem cell selection paradigm.
Article in Aging cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of aging on the male reproductive system.Journal of assisted reproduction and genetics · 2016Pooled it
- Article
- Resveratrol intake by males increased the mitochondrial DNA copy number and telomere length of blastocysts derived from aged mice.The Journal of reproduction and development · 2024Article
- Article
- Involvement of Inheritance in Determining Telomere Length beyond Environmental and Lifestyle Factors.Aging and disease · 2023Review
- Mendelian Randomization Study Implies Causal Linkage Between Telomere Length and Juvenile Idiopathic Arthritis in a European Population.Journal of inflammation research · 2022Article
- Article
- Telomere length: how the length makes a difference.Molecular biology reports · 2020Review
- Testing for paternal influences on offspring telomere length in a human cohort in the Philippines.American journal of physical anthropology · 2020Article
- The Danish Twin Registry: An Updated Overview.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019Article
- Advanced Parental Age at Conception and Sex Affects Mitochondrial DNA Copy Number in Human and Fruit Flies.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Epigenetic inheritance of telomere length in wild birds.PLoS genetics · 2019Article
- Paternal Age and Transgenerational Telomere Length Maintenance: A Simulation Model.Scientific reports · 2019Article
- Article
- The mitochondrial genome, paternal age and telomere length in humans.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Reflections on telomere dynamics and ageing-related diseases in humans.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- The paternal age at conception effect on offspring telomere length: mechanistic, comparative and adaptive perspectives.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- No evidence for parental age effects on offspring leukocyte telomere length in free-living Soay sheep.Scientific reports · 2017Article
- Telomere length as a potential biomarker of coronary artery disease.The Indian journal of medical research · 2017Review
- Paternal and grandpaternal ages at conception and descendant telomere lengths in chimpanzees and humans.American journal of physical anthropology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Telomere length, a highly heritable trait, is longer in offspring of older fathers. This perplexing feature has been attributed to the longer telomeres in sperm of older men and it might be an 'epigenetic' mechanism through which paternal age plays a role in telomere length regulation in humans. Based on two independent (discovery and replication) twin studies, comprising 889 twin pairs, we show an increase in the resemblance of leukocyte telomere length between dizygotic twins of older fathers, which is not seen in monozygotic twins. This phenomenon might result from a paternal age-dependent germ stem cell selection process, whereby the selected stem cells have longer telomeres, are more homogenous with respect to telomere length, and share resistance to aging.
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Registered trials
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