ArticleThe European journal of neuroscience2015
Sustained activation of GABAA receptors in the suprachiasmatic nucleus mediates light-induced phase delays of the circadian clock: a novel function of ionotropic receptors.
Article in The European journal of neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of drugs that modify the circadian system's phase-shifting responses to light exposure.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Pooled it
- Article
- Direct energy consumption by inhibitory GABAFrontiers in neuroscience · 2026Article
- Associations between perioperative sleep patterns and clinical outcomes in patients with intracranial tumors: a correlation study.Frontiers in neurology · 2023Article
- Retina-attached slice recording reveals light-triggered tonic GABA signaling in suprachiasmatic nucleus.Molecular brain · 2021Article
- Diurnal properties of tonic and synaptic GABAJournal of neurophysiology · 2021Article
- A Novel Application of Ketamine for Improving Perioperative Sleep Disturbances.Nature and science of sleep · 2021Review
- A Symphony of Signals: Intercellular and Intracellular Signaling Mechanisms Underlying Circadian Timekeeping in Mice and Flies.International journal of molecular sciences · 2019Review
- Functional Significance of the Excitatory Effects of GABA in the Suprachiasmatic Nucleus.Journal of biological rhythms · 2018Article
- GABA transporters regulate tonic and synaptic GABAJournal of neurophysiology · 2017Article
- The dynamics of GABA signaling: Revelations from the circadian pacemaker in the suprachiasmatic nucleus.Frontiers in neuroendocrinology · 2017Review
- Circadian Plasticity of Mammalian Inhibitory Interneurons.Neural plasticity · 2017Review
- Localization and expression of GABA transporters in the suprachiasmatic nucleus.The European journal of neuroscience · 2015Article
- Article
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9 authors.
Funding
Abstract
The suprachiasmatic nucleus (SCN) contains a circadian clock that generates endogenous rhythmicity and entrains that rhythmicity with the day-night cycle. The neurochemical events that transduce photic input within the SCN and mediate entrainment by resetting the molecular clock have yet to be defined. Because GABA is contained in nearly all SCN neurons we tested the hypothesis that GABA serves as this signal in studies employing Syrian hamsters (Mesocricetus auratus). Activation of GABAA receptors was found to be necessary and sufficient for light to induce phase delays of the clock. Remarkably, the sustained activation of GABAA receptors for more than three consecutive hours was necessary to phase-delay the clock. The duration of GABAA receptor activation required to induce phase delays would not have been predicted by either the prevalent theory of circadian entrainment or by expectations regarding the duration of ionotropic receptor activation necessary to produce functional responses. Taken together, these data identify a novel neurochemical mechanism essential for phase-delaying the 'master' circadian clock within the SCN as well as identifying an unprecedented action of an amino acid neurotransmitter involving the sustained activation of ionotropic receptors.
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