ReviewObesity (Silver Spring, Md.)2015
Progress in the molecular understanding of central regulation of body weight by estrogens.
Review in Obesity (Silver Spring, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Hypothalamic actions of estrogens in the regulation of energy and glucose homeostasis.Reviews in endocrine & metabolic disorders · 2026Review
- Epigenetic programming of estrogen receptor in adipocytes by high-fat diet regulates obesity-induced inflammation.JCI insight · 2025Article
- Identification of an ionic mechanism for ERα-mediated rapid excitation in neurons.Science advances · 2024Article
- Neuroactive steroids in the neuroendocrine control of food intake, metabolism, and reproduction.Endocrine · 2024Review
- Estrogen signaling in the dorsal raphe regulates binge-like drinking in mice.Translational psychiatry · 2024Article
- The role of oestrogen in determining sexual dimorphism in energy balance.The Journal of physiology · 2023Review
- The hypothalamus for whole-body physiology: from metabolism to aging.Protein & cell · 2022Review
- Loss of the Protective Effect of Estrogen Contributes to Maternal Gestational Hypertension-Induced Hypertensive Response Sensitization Elicited by Postweaning High-Fat Diet in Female Offspring.Journal of the American Heart Association · 2022Article
- Impact of Estrogens Present in Environment on Health and Welfare of Animals.Animals : an open access journal from MDPI · 2021Review
- Hypothalamic Perineuronal Nets Are Regulated by Sex and Dietary Interventions.Frontiers in physiology · 2021Article
- Mechanisms for Sex Differences in Energy Homeostasis.Journal of molecular endocrinology · 2019Review
- Central regulation of energy metabolism by estrogens.Molecular metabolism · 2018Review
- Impact of estrogens and estrogen receptor-α in brain lipid metabolism.American journal of physiology. Endocrinology and metabolism · 2018Review
- Emerging Roles of Estrogen-Related Receptors in the Brain: Potential Interactions with Estrogen Signaling.International journal of molecular sciences · 2018Review
- Sex Hormones and Cardiometabolic Health: Role of Estrogen and Estrogen Receptors.Endocrinology · 2017Review
- Brain nuclear receptors and body weight regulation.The Journal of clinical investigation · 2017Review
- Sex differences in obesity development in pair-fed neuronal lipoprotein lipase deficient mice.Molecular metabolism · 2016Article
- Visualizing estrogen receptor-α-expressing neurons using a new ERα-ZsGreen reporter mouse line.Metabolism: clinical and experimental · 2016Article
- PI3K in the ventromedial hypothalamic nucleus mediates estrogenic actions on energy expenditure in female mice.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectiveEstrogens can act in the brain to prevent body weight gain. Tremendous research efforts have been focused on estrogen physiology in the brain in the context of body weight control; estrogen receptors and the related signals have been attractive targets for development of new obesity therapies. The objective is to review recent findings on these aspects.
methodsRecent studies that used conventional and conditional knockout mouse strains to delineate the cellular and molecular mechanisms for the beneficial effects of estrogens on body weight balance are reviewed. Emerging genetic tools that could further benefit the field of estrogen research and a newly developed estrogen-based regimen that produces body weight-lowering benefits also are discussed.
resultsThe body weight-lowering effects of estrogens are mediated by multiple forms of estrogen receptors in different brain regions through distinct but coordinated mechanisms. Both rapid signals and "classic" nuclear receptor actions of estrogen receptors appear to contribute to estrogenic regulation of body weight.
conclusionsEstrogen receptors and associated signal networks are potential targets for obesity treatment, and further investigations are warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.