Evidence map›Paper›PMID 25865577›Full record

ReviewBone2015

Multiple levels of epigenetic control for bone biology and pathology.

Martin Montecino, Gary Stein, Janet Stein, Kaleem Zaidi, Rodrigo Aguilar

Open access · greenAbstract readReview
In one paragraph

Review in Bone, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Role of m6A in osteoporosis, arthritis and osteosarcoma (Review).Experimental and therapeutic medicine · 2021
    Review
  5. Article
  6. Article
  7. Review
  8. ODNA: a manually curated database of noncoding RNAs associated with orthopedics.Database : the journal of biological databases and curation · 2019
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Martin MontecinoCenter for Biomedical Research and FONDAP Center for Genome Regulation, Faculty of Biological Sciences and Faculty of Medicine, Universidad Andres Bello, Avenida Republica 239, Santiago, Chile. Electronic address: mmontecino@unab.cl.
Gary SteinDepartment of Biochemistry and Vermont Cancer Center, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT, USA. Electronic address: gary.stein@uvm.edu.
Janet SteinDepartment of Biochemistry and Vermont Cancer Center, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT, USA.
Kaleem ZaidiDepartment of Biochemistry and Vermont Cancer Center, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT, USA.
Rodrigo AguilarCenter for Biomedical Research and FONDAP Center for Genome Regulation, Faculty of Biological Sciences and Faculty of Medicine, Universidad Andres Bello, Avenida Republica 239, Santiago, Chile.
University of Vermont · USUniversidad Andrés Bello · CL

Funding

SUBNUCLEAR TARGETING OF TRANSCRIPTION FACTORSP01CA082834 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI STEIN, GARY S. · 2001 to 2015
$18.4M
CONTROL OF OSTEOBLAST PROLIFERATION AND DIFFERENTIATIONR01AR039588 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LIAN, JANE B., STEIN, GARY S. · 1990 to 2019
$8.0M
Deregulated microRNAs in Acute Myeloid LeukemiaR03CA167726 · NCI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ZAIDI, SAYYED KALEEM · 2013 to 2014
$150k
NCI NIH HHS P01 CA082834NCI NIH HHS R03 CA167726NIAMS NIH HHS R01 AR039588
6 · The paper itself

Abstract

Multiple dimensions of epigenetic control contribute to regulation of gene expression that governs bone biology and pathology. Once confined to DNA methylation and a limited number of post-translational modifications of histone proteins, the definition of epigenetic mechanisms is expanding to include contributions of non-coding RNAs and mitotic bookmarking, a mechanism for retaining phenotype identity during cell proliferation. Together these different levels of epigenetic control of physiological processes and their perturbations that are associated with compromised gene expression during the onset and progression of disease, have contributed to an unprecedented understanding of the activities (operation) of the genomic landscape. Here, we address general concepts that explain the contribution of epigenetic control to the dynamic regulation of gene expression during eukaryotic transcription. This article is part of a Special Issue entitled Epigenetics and Bone.

Indexed as

Epigenesis, GeneticBone and BonesCell ProliferationDNA MethylationHistonesHumansProtein Processing, Post-TranslationalRNA, UntranslatedHistonesRNA, UntranslatedDNA methylationHistone modificationsIntanuclear domainsMitotic bookmarkingRUNX2 epigenetics

Identifiers

PMID25865577
PMCPMC4600412
OpenAlexW2113959981

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.