ArticleOrthodontics & craniofacial research2015
Phenotype-genotype correlations of facial width and height proportions in patients with Class II malocclusion.
Article in Orthodontics & craniofacial research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Genetic factors contributing to skeletal class III malocclusion: a systematic review and meta-analysis.Clinical oral investigations · 2021Pooled it
- Cross-Sectional Study of Variations in Cephalometric Parameters in Arab Orthodontic Patients with Skeletal Class I and II.Journal of clinical medicine · 2025Article
- Association between Taql polymorphism of vitamin D receptor gene and vertical growth of the mandible: A cross-sectional study.Korean journal of orthodontics · 2023Article
- Hmga2 deficiency is associated with allometric growth retardation, infertility, and behavioral abnormalities in mice.G3 (Bethesda, Md.) · 2022Article
- HMGA Genes and Proteins in Development and Evolution.International journal of molecular sciences · 2020Review
- Linear and Volumetric Mandibular Asymmetries in Adult Patients With Different Skeletal Classes and Vertical Patterns: A Cone-Beam Computed Tomography Study.Scientific reports · 2018Article
- Candidate gene analyses of 3-dimensional dentoalveolar phenotypes in subjects with malocclusion.American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics · 2017Article
- Genomewide Association Study of African Children Identifies Association of SCHIP1 and PDE8A with Facial Size and Shape.PLoS genetics · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo characterize soft-tissue facial height and width variation in Class II malocclusion and test for correlations with genes HMGA2, AJUBA, and ADK. SETTING AND SAMPLE POPULATION: Nine facial proportions were estimated from 2D frontal repose photographs of 330 Caucasian adults with Class II malocclusion. MATERIAL AND
methodsAfter adjustments for age and gender, the facial proportions were submitted to a principal component analyses (PCA). The most meaningful phenotypic variations were correlated with SNPs rs7924176 (ADK), rs17101923 (HMGA2), and rs997154 (AJUBA) genotyped in 106 individuals.
resultsPrincipal component analyses resulted in four principal components (PCs), which explained 75% of total variation. PC1 captured variation in the intercanthus distance and explained 28% of total variation. PC2 explained 21% of the variations in facial taper and facial index. PC3 explained 14% and reflected variations in the vertical dimension of the lower face. PC4 explained 12% and captured variations in distance between the eyes, width of the commissures, and the length of the superior aspect of the lower face height corresponding to the vertical dimension of the philtrum of the upper lip. A suggestive association (p<0.05) was observed between PC4 and rs997154 corroborating the role of AJUBA in variation of facial dimensions.
conclusion2D frontal photographs can be used to derive quantitative measures of soft-tissue phenotypes that are of clinical relevance. The methods described are suitable for discovery and replication of associations between genotypes and malocclusion phenotypes.
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