Evidence map›Paper›PMID 25865537›Full record

ArticleOrthodontics & craniofacial research2015

Genetics of the dentofacial variation in human malocclusion.

L M Moreno Uribe, S F Miller

Open access · greenAbstract read
In one paragraph

Article in Orthodontics & craniofacial research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.

  1. Pooled it
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  10. Polymorphisms inJournal of Taibah University Medical Sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

L M Moreno UribeDepartment of Orthodontics, College of Dentistry, University of Iowa, Iowa City, IA, USA; Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City, IA, USA.
S F Miller
University of Iowa · US

Funding

University of Iowa Clinical and Translational Science ProgramUL1TR000442 · NCATS · UNIVERSITY OF IOWA · PI ROSENTHAL, GARY E · 2012 to 2013
$10.0M
University of Iowa Institutional Training Program in Oral Health ResearchT90DE023520 · NIDCR · UNIVERSITY OF IOWA · PI STEVEN M. LEVY · 2013 to 2026
$5.6M
Institutional Training Program in Oral Health ResearchT32DE014678 · NIDCR · UNIVERSITY OF IOWA · PI SQUIER, CHRISTOPHER · 2002 to 2011
$5.2M
University of Iowa Institutional Training Program in Oral Health ResearchR90DE024296 · NIDCR · UNIVERSITY OF IOWA · PI STEVEN M. LEVY · 2013 to 2026
$1.8M
Health outcomes and improved phenotypic characterization of cleft lip and palateR01DD000295 · DD · UNIVERSITY OF IOWA · PI WEHBY, GEORGE L · 2007 to 2009
$1.4M
NCATS NIH HHS 2 UL1 TR000442-06NCATS NIH HHS UL1 TR000442NCBDD CDC HHS R01 DD000295NIDCR NIH HHS R90 DE024296NIDCR NIH HHS T32 DE014678NIDCR NIH HHS T90 DE023520PHS HHS CDCR01D000295PHS HHS T32-DEO14678-09
6 · The paper itself

Abstract

Malocclusions affect individuals worldwide, resulting in compromised function and esthetics. Understanding the etiological factors contributing to the variation in dentofacial morphology associated with malocclusions is the key to develop novel treatment approaches. Advances in dentofacial phenotyping, which is the comprehensive characterization of hard and soft tissue variation in the craniofacial complex, together with the acquisition of large-scale genomic data have started to unravel genetic mechanisms underlying facial variation. Knowledge on the genetics of human malocclusion is limited even though results attained thus far are encouraging, with promising opportunities for future research. This review summarizes the most common dentofacial variations associated with malocclusions and reviews the current knowledge of the roles of genes in the development of malocclusions. Lastly, this review will describe ways to advance malocclusion research, following examples from the expanding fields of phenomics and genomic medicine, which aim to better patient outcomes.

Indexed as

Anatomic VariationGenetic VariationGenomicsGenotypeHumansMalocclusionMalocclusion, Angle Class IIMalocclusion, Angle Class IIIPhenotypecandidate genescephalometrycraniofacialgeneticsgenomic medicinegenotype-phenotype correlationphenomics

Identifiers

PMID25865537
PMCPMC4418210
OpenAlexW2058541172

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.