ArticleThe European journal of neuroscience2015
Novel fast adapting interneurons mediate cholinergic-induced fast GABAA inhibitory postsynaptic currents in striatal spiny neurons.
Article in The European journal of neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 60 citations in OpenAlex.
- Mu-opioid and nociceptin receptors show divergent, cell-type-specific actions in the mesocorticolimbic reward system in opioid use disorder.Frontiers in cellular neuroscience · 2026Review
- Regional heterogeneity of striatal cholinergic interneurons: setting the stage for diverse behavioral repertoires.Frontiers in cellular neuroscience · 2026Review
- Acetylcholine waves and dopamine release in the striatum.Nature communications · 2023Article
- Cholinergic control of striatal GABAergic microcircuits.Cell reports · 2022Article
- Article
- Article
- Nicotinic Acetylcholine Receptors Expressed by Striatal Interneurons Inhibit Striatal Activity and Control Striatal-Dependent Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Cortical excitability changes as a marker of cognitive impairment in Parkinson's disease.Behavioural brain research · 2022Article
- Dopamine D2 receptors modulate the cholinergic pause and inhibitory learning.Molecular psychiatry · 2022Article
- Review
- Striatal cholinergic transmission. Focus on nicotinic receptors' influence in striatal circuits.The European journal of neuroscience · 2021Review
- Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity.The American journal of psychiatry · 2021Article
- Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner.Nature communications · 2020Article
- Cholinergic midbrain afferents modulate striatal circuits and shape encoding of action strategies.Nature communications · 2020Article
- Dopamine-glutamate neuron projections to the nucleus accumbens medial shell and behavioral switching.Neurochemistry international · 2019Review
- Cholinergic modulation of striatal microcircuits.The European journal of neuroscience · 2019Review
- Excitatory extrinsic afferents to striatal interneurons and interactions with striatal microcircuitry.The European journal of neuroscience · 2019Review
- A Novel Type of Neuron Within the Dorsal Striatum.Frontiers in neural circuits · 2019Article
- New Insights Into Cholinergic Neuron Diversity.Frontiers in molecular neuroscience · 2019Review
- Identification and Characterization of a Novel Spontaneously Active Bursty GABAergic Interneuron in the Mouse Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Previous work suggests that neostriatal cholinergic interneurons control the activity of several classes of GABAergic interneurons through fast nicotinic receptor-mediated synaptic inputs. Although indirect evidence has suggested the existence of several classes of interneurons controlled by this mechanism, only one such cell type, the neuropeptide-Y-expressing neurogliaform neuron, has been identified to date. Here we tested the hypothesis that in addition to the neurogliaform neurons that elicit slow GABAergic inhibitory responses, another interneuron type exists in the striatum that receives strong nicotinic cholinergic input and elicits conventional fast GABAergic synaptic responses in projection neurons. We obtained in vitro slice recordings from double transgenic mice in which Channelrhodopsin-2 was natively expressed in cholinergic neurons and a population of serotonin receptor-3a-Cre-expressing GABAergic interneurons were visualized with tdTomato. We show that among the targeted GABAergic interneurons a novel type of interneuron, termed the fast-adapting interneuron, can be identified that is distinct from previously known interneurons based on immunocytochemical and electrophysiological criteria. We show using optogenetic activation of cholinergic inputs that fast-adapting interneurons receive a powerful supra-threshold nicotinic cholinergic input in vitro. Moreover, fast adapting neurons are densely connected to projection neurons and elicit fast, GABAA receptor-mediated inhibitory postsynaptic current responses. The nicotinic receptor-mediated activation of fast-adapting interneurons may constitute an important mechanism through which cholinergic interneurons control the activity of projection neurons and perhaps the plasticity of their synaptic inputs when animals encounter reinforcing or otherwise salient stimuli.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.