ReviewClinical and experimental immunology2015
Immunology of IgG4-related disease.
Review in Clinical and experimental immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03260088 (Evaluation Of Pleural Effusion At Assiut University Hospital), which is not on this map. Cited by 110 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation Of Pleural Effusion At Assiut University Hospital
Who cites it
110 citing papers in PubMed, 5 syntheses or guidelines pooled it, 223 citations in OpenAlex.
- Genetic Association in Immunoglobulin G4-Related Disease: A Systematic Review.International archives of allergy and immunology · 2026Pooled it
- Risk factors for relapse of IgG4-related disease: a systematic review and meta‑analysis.Clinical rheumatology · 2025Pooled it
- IgG4-related disorders of the gastrointestinal tract: Experience from a tertiary care centre with systematic review of Indian literature.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Pooled it
- European Guideline on IgG4-related digestive disease - UEG and SGF evidence-based recommendations.United European gastroenterology journal · 2020Guideline
- Pulmonary vascular involvement of IgG4-related disease: Case series with a PRISMA-compliant systemic review.Medicine · 2019Pooled it
- Similarities and differences of a proliferation-inducing ligand expression in lacrimal gland lesions of patients with IgG4-associated ophthalmic diseases and mucosa-associated lymphoid tissue lymphoma.Frontiers in immunology · 2025Trial
- Serum Concentrations of IgG4 in the Spanish Adult Population: Relationship with Age, Gender, and Atopy.PloS one · 2016Trial
- IgG4-related kidney disease presenting as severe renal failure: Diagnostic challenges of a multimodality imaging approach.Radiology case reports · 2026Article
- Article
- IgG4-related sclerosing cholangitis: navigating diagnostic dilemmas and the challenge of relapse.Frontiers in medicine · 2026Review
- IgG4-Related Disease: A Case Series Highlighting Diverse Clinical Manifestations and Treatment Outcomes.Cureus · 2025Article
- IgG4-Related Cholangitis.Seminars in liver disease · 2025Review
- IgG4-related disease and other fibro-inflammatory conditions.Nature reviews. Rheumatology · 2025Review
- Targeted animal models for preclinical assessment of cellular and gene therapies in pancreatic and liver diseases: regulatory and practical insights.Cytotherapy · 2025Review
- IgG4-RD-Associated Mikulicz Syndrome Without Classic Systemic Involvement-A Case Report.Journal of clinical medicine · 2025Article
- The Platelet-Specific Gene Signature in the Immunoglobulin G4-Related Disease Transcriptome.Medicina (Kaunas, Lithuania) · 2025Article
- IgG4-related disease - focus on digestive system involvement.Frontiers in immunology · 2025Review
- IgG4-related retroperitoneal fibrosis presenting as a peripancreatic mass: a case series.Annals of medicine and surgery (2012) · 2025Article
- An Unusual Case of Chylous Ascites.Cureus · 2024Article
- A Rare Presentation of IgG4-Related Sinusitis With Chronic Nasal Obstruction and Headache: A Case Report and Literature Review.Journal of rhinology : official journal of the Korean Rhinologic Society · 2024Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunoglobulin G4-related disease (IgG4-RD) is a fibroinflammatory condition that derives its name from the characteristic finding of abundant IgG4(+) plasma cells in affected tissues, as well as the presence of elevated serum IgG4 concentrations in many patients. In contrast to fibrotic disorders, such as systemic sclerosis or idiopathic pulmonary fibrosis in which the tissues fibrosis has remained largely intractable to treatment, many IgG4-RD patients appear to have a condition in which the collagen deposition is reversible. The mechanisms underlying this peculiar feature remain unknown, but the remarkable efficacy of B cell depletion in these patients supports an important pathogenic role of B cell/T cell collaboration. In particular, aberrant T helper type 2 (Th2)/regulatory T cells sustained by putative autoreactive B cells have been proposed to drive collagen deposition through the production of profibrotic cytokines, but definitive demonstrations of this hypothesis are lacking. Indeed, a number of unsolved questions need to be addressed in order to fully understand the pathogenesis of IgG4-RD. These include the identification of an antigenic trigger(s), the implications (if any) of IgG4 antibodies for pathophysiology and the precise immunological mechanisms leading to fibrosis. Recent investigations have also raised the possibility that innate immunity might precede adaptive immunity, thus further complicating the pathological scenario. Here, we aim to review the most recent insights on the immunology of IgG4-RD, focusing on the relative contribution of innate and adaptive immune responses to the full pathological phenotype of this fibrotic condition. Clinical, histological and therapeutic features are also addressed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.