ArticleGeneral and comparative endocrinology2015
Developmental timing of sodium perchlorate exposure alters angiogenesis, thyroid follicle proliferation and sexual maturation in stickleback.
Article in General and comparative endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 40 citations in OpenAlex.
- Functional mutations in the thyroid-stimulating hormone receptor in natural stickleback populations at sites identical to human disease-causing mutations.BMC ecology and evolution · 2025Article
- Transcriptomic and developmental effects of persistent organic pollutants in sentinel fishes collected near an arctic formerly used defense site.Environmental pollution (Barking, Essex : 1987) · 2024Article
- Differential gene expression and developmental pathologies associated with persistent organic pollutants in sentinel fish in Troutman Lake, Sivuqaq, Alaska.Environmental pollution (Barking, Essex : 1987) · 2024Article
- Identification of a pharyngeal mucosal lymphoid organ in zebrafish and other teleosts: Tonsils in fish?Science advances · 2023Article
- Evaluating Dermal Bone as a Novel Source of Endocrine Information in Ninespine and Threespine Stickleback Fish.Integrative organismal biology (Oxford, England) · 2023Article
- Evolution and developmental expression of the sodium-iodide symporter (Evolutionary applications · 2022Article
- Health Impacts of Perchlorate and Pesticide Exposure: Protocol for Community-Engaged Research to Evaluate Environmental Toxicants in a US Border Community.JMIR research protocols · 2021Article
- Perchlorate exposure does not induce obesity or non-alcoholic fatty liver disease in zebrafish.PloS one · 2021Article
- Genetic divergence outpaces phenotypic evolution among threespine stickleback populations in old freshwater habitats.Biological journal of the Linnean Society. Linnean Society of London · 2019Article
- Sodium perchlorate induces non-alcoholic fatty liver disease in developing stickleback.Environmental pollution (Barking, Essex : 1987) · 2019Article
- Exogenous iodide ameliorates perchlorate-induced thyroid phenotypes in threespine stickleback.General and comparative endocrinology · 2017Article
- Perchlorate Exposure Reduces Primordial Germ Cell Number in Female Threespine Stickleback.PloS one · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Perchlorate, a common aquatic contaminant, is well known to disrupt homeostasis of the hypothalamus-pituitary-thyroid axis. This study utilizes the threespine stickleback (Gasterosteus aculeatus) fish to determine if perchlorate exposure during certain windows of development has morphological effects on thyroid and gonads. Fish were moved from untreated water to perchlorate-contaminated water (30 and 100mg/L) starting at 0, 3, 7, 14, 21, 42, 154 and 305 days post fertilization until approximately one year old. A reciprocal treatment (fish in contaminated water switched to untreated water) was conducted on the same schedule. Perchlorate exposure increased angiogenesis and follicle proliferation in thyroid tissue, delayed gonadal maturity, and skewed sex ratios toward males; effects depended on concentration and timing of exposure. This study demonstrates that perchlorate exposure beginning during the first 42 days of development has profound effects on stickleback reproductive and thyroid tissues, and by implication can impact population dynamics. Long-term exposure studies that assess contaminant effects at various stages of development provide novel information to characterize risk to aquatic organisms, to facilitate management of resources, and to determine sensitive developmental windows for further study of underlying mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.