ArticleNeuroscience2015
Cortical neuronal activity does not regulate sleep homeostasis.
Article in Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Linking Hypothermia and Altered Metabolism with TrkB Activation.ACS chemical neuroscience · 2023Article
- Melatonin supplementation in the subacute phase after ischemia alleviates postischemic sleep disturbances in rats.Brain and behavior · 2021Article
- Global sleep homeostasis reflects temporally and spatially integrated local cortical neuronal activity.eLife · 2020Article
- Level of Consciousness Is Dissociable from Electroencephalographic Measures of Cortical Connectivity, Slow Oscillations, and Complexity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Article
- Differential Role of Prefrontal and Parietal Cortices in Controlling Level of Consciousness.Current biology : CB · 2018Article
- Sleep, synaptic homeostasis and neuronal firing rates.Current opinion in neurobiology · 2017Review
- Why Does Sleep Slow-Wave Activity Increase After Extended Wake? Assessing the Effects of Increased Cortical Firing During Wake and Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Article
- Neural Correlates of Wakefulness, Sleep, and General Anesthesia: An Experimental Study in Rat.Anesthesiology · 2016Article
- Unraveling the Evolutionary Determinants of Sleep.Current biology : CB · 2016Review
- Genetic Dissociation of Daily Sleep and Sleep Following Thermogenetic Sleep Deprivation in Drosophila.Sleep · 2016Article
- Sleep, recovery, and metaregulation: explaining the benefits of sleep.Nature and science of sleep · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
The neural substrate of sleep homeostasis is unclear, but both cortical and subcortical structures are thought to be involved in sleep regulation. To test whether prior neuronal activity in the cortex or in subcortical regions drives sleep rebound, we systemically administered atropine (100mg/kg) to rats, producing a dissociated state with slow-wave cortical electroencephalogram (EEG) but waking behavior (e.g. locomotion). Atropine injections during the light period produced 6h of slow-wave cortical EEG but also subcortical arousal. Afterward, rats showed a significant increase in non-rapid eye movement (NREM) sleep, compared to the same period on a baseline day. Consistent with the behavioral and cortical EEG state produced by systemic atropine, c-Fos expression was low in the cortex but high in multiple subcortical arousal systems. These data suggest that subcortical arousal and behavior are sufficient to drive sleep homeostasis, while a sleep-like pattern of cortical activity is not sufficient to satisfy sleep homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.