Evidence map›Paper›PMID 25864883›Full record

ReviewTrends in microbiology2015

Staphylococcus aureus infections: transmission within households and the community.

Justin Knox, Anne-Catrin Uhlemann, Franklin D Lowy

Open access · bronzeAbstract readReview
In one paragraph

Review in Trends in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 139 citations in OpenAlex.

  1. Trial
  2. Photodynamic anti-biofilm PHEMA/Rose Bengal hydrogels enhanced by iodide: evidence for hydrogen peroxide and triiodide formation.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
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  12. Review
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  14. Genomic and functional divergence ofMicrobiology spectrum · 2024
    Article
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  19. Article
  20. Different evolution ofHeliyon · 2024
    Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Justin KnoxDivision of Infectious Diseases, Department of Medicine, Columbia University, College of Physicians & Surgeons, New York, NY, USA.
Anne-Catrin UhlemannDivision of Infectious Diseases, Department of Medicine, Columbia University, College of Physicians & Surgeons, New York, NY, USA.
Franklin D LowyDivision of Infectious Diseases, Department of Medicine, Columbia University, College of Physicians & Surgeons, New York, NY, USA; Department of Pathology & Cell Biology, Columbia University, College of Physicians & Surgeons, NY, NY, USA. Electronic address: fl189@columbia.edu.
Columbia University · US

Funding

Modeling of S.Aureus Transmission in Northern ManhattanR01AI077690 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LOWY, FRANKLIN D · 2009 to 2013
$3.4M
Mechanisms of S. aureus transmission and persistence.K08AI090013 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI UHLEMANN, ANNE-CATRIN · 2010 to 2014
$655k
The use of whole genome sequencing to identify spread of USA300 in the communityR21AI103562 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LOWY, FRANKLIN D · 2013 to 2014
$454k
NIAID NIH HHS K08 AI090013NIAID NIH HHS R01 AI077690NIAID NIH HHS R01 AI077690-S1NIAID NIH HHS R21 AI103562
6 · The paper itself

Abstract

Staphylococcus aureus, both methicillin susceptible and resistant, are now major community-based pathogens worldwide. The basis for this is multifactorial and includes the emergence of epidemic clones with enhanced virulence, antibiotic resistance, colonization potential, or transmissibility. Household reservoirs of these unique strains are crucial to their success as community-based pathogens. Staphylococci become resident in households, either as colonizers or environmental contaminants, increasing the risk for recurrent infections. Interactions of household members with others in different households or at community sites, including schools and daycare facilities, have a critical role in the ability of these strains to become endemic. Colonization density at these sites appears to have an important role in facilitating transmission. The integration of research tools, including whole-genome sequencing (WGS), mathematical modeling, and social network analysis, has provided additional insight into the transmission dynamics of these strains. Thus far, interventions designed to reduce recurrent infections among household members have had limited success, likely due to the multiplicity of potential sources for recolonization. The development of better strategies to reduce the number of household-based infections will depend on greater insight into the different factors that contribute to the success of these uniquely successful epidemic clones of S. aureus.

Indexed as

Family CharacteristicsMethicillin-Resistant Staphylococcus aureusStaphylococcus aureusCommunity-Acquired InfectionsDisease ReservoirsDrug Resistance, BacterialGenome, BacterialHumansRisk FactorsSequence Analysis, DNAStaphylococcal Infectionscommunity-associatedhousehold transmissionStaphylococcus aureus

Identifiers

PMID25864883
PMCPMC4490959
OpenAlexW2032561782

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.