Evidence map›Paper›PMID 25864820›Full record

ArticleOral surgery, oral medicine, oral pathology and oral radiology2015

Mandibular inferior cortical bone thickness on panoramic radiographs in patients using bisphosphonates.

Sandra R Torres, Curtis S K Chen, Brian G Leroux, Peggy P Lee, Lars G Hollender, Michelle Lloid, Shane Patrick Drew, Mark M Schubert

Abstract readMulticenter Study
In one paragraph

Article in Oral surgery, oral medicine, oral pathology and oral radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
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  8. Radiographic perception of anatomical structures and bony changes in oncologic patients under antiresorptive therapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Article
  9. Radiographic changes of mandibular cortical bone in bisphosphonate drug holiday.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Sandra R TorresDepartment of Oral Pathology and Diagnosis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Visiting Faculty at University of Washington, Seattle, WA, USA. Electronic address: sandratorres@odonto.ufrj.br.
Curtis S K ChenOral Radiology Specialty Program, Department of Oral Medicine, School of Dentistry, University of Washington, Seattle, WA, USA.
Brian G LerouxDental Public Health Sciences and Biostatistics, School of Dentistry, University of Washington, Seattle, WA, USA.
Peggy P LeeDepartment of Oral Medicine, School of Dentistry, University of Washington, Seattle, USA.
Lars G HollenderDepartment of Oral Medicine, School of Dentistry, University of Washington, Seattle, USA.
Michelle LloidDepartment of Oral Medicine, School of Dentistry, University of Washington, Seattle, USA.
Shane Patrick DrewDepartment of Oral Medicine, School of Dentistry, University of Washington, Seattle, USA.
Mark M SchubertDepartment of Oral Medicine, School of Dentistry, University of Washington, Director, Oral Medicine Service, Seattle Cancer Care Alliance, Seattle, WA, USA.
University of Washington · USSeattle Cancer Care Alliance · USSeattle University · US

Funding

Institute for Translational Health Science (TL1)TL1RR025016 · NCRR · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2007 to 2011
$2.7M
Institute of Translational Health SciencesTL1TR000422 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$2.1M
NCATS NIH HHS TL1 TR000422NCRR NIH HHS TL1 RR 025016NCRR NIH HHS TL1 RR025016
6 · The paper itself

Abstract

objectiveThe goal of this study was to detect dimensional changes in the mandibular cortical bone associated with bisphosphonate (BP) use and to correlate measurements of the cortical bone with the cumulative dose of BPs. STUDY

designMandibular inferior cortical bone thickness (MICBT) was measured under the mental foramen on panoramic radiographs of patients with and without bisphosphonate-related osteonecrosis of the jaws (BRONJ) taking BPs and controls.

resultsPatients with BRONJ had the highest mean MICBT (6.81 ± 1.35 mm), compared with patients without BRONJ taking BPs (5.44 ± 1.09 mm) and controls (4.79 ± 0.85 mm) (P < .01). Mean MICBT of patients with BRONJ was significantly higher than that of patients without BRONJ taking BPs. There was a correlation between MICBT and cumulative dose of zolendronate.

conclusionsMeasurement of MICBT on panoramic radiographs is a potentially useful tool for the detection of dimensional changes associated with BP therapy.

Indexed as

AdultAgedAged, 80 and overBisphosphonate-Associated Osteonecrosis of the JawFemaleHumansMaleMandibleMiddle AgedRadiography, PanoramicSurveys and Questionnaires

Identifiers

PMID25864820
PMCPMC4395858
OpenAlexW2150742728

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.